Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 251-262 |
| Seitenumfang | 12 |
| Fachzeitschrift | Journal of Sensors and Sensor Systems |
| Jahrgang | 9 |
| Ausgabenummer | 2 |
| Publikationsstatus | Veröffentlicht - 19 Aug. 2020 |
Abstract
The individualization of dialysis treatment using a customized dialysate composition usually requires a continuous measurement of electrolytes and urea in blood. The current practices are spot measurements of blood samples either with blood gas analyzers or in the laboratory, involving considerable personnel effort. Furthermore, the measured values are time delayed and not available in a continuous fashion. In this paper we investigate an in-line concept for continuous monitoring of important blood parameters such as sodium, potassium, calcium and urea concentrations in blood serum using ion-selective electrodes. This concept is evaluated in a preclinical study with human packed red blood cells as a test medium over a period of 7 h. It has been shown that the electrolytes can be well monitored. In addition, we present first measurements with ion-sensitive field-effect transistors in a miniaturized sensor assembly. Therefore, new low-cost electronics for such ion-sensitive field-effect transistors have been developed.
ASJC Scopus Sachgebiete
- Physik und Astronomie (insg.)
- Instrumentierung
- Ingenieurwesen (insg.)
- Elektrotechnik und Elektronik
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in: Journal of Sensors and Sensor Systems, Jahrgang 9, Nr. 2, 19.08.2020, S. 251-262.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - In-line monitoring of electrolytes and urea during continuous renal replacement therapy
AU - Berger, Marc
AU - Sehlmeyer, Merle
AU - Sellering, Flora
AU - Röhrich, Hannes
AU - Perl, Thorsten
AU - Mansour, Hussam
AU - Baasner, Daniel
AU - Zimmermann, Stefan
N1 - Funding Information: Financial support. This research has been supported by the Bundesministerium für Bildung und Forschung (BMBF; grant no. 13GW0085B). Funding Information: The publication of this article was funded by the open-access fund of Leibniz Universität Hannover.
PY - 2020/8/19
Y1 - 2020/8/19
N2 - The individualization of dialysis treatment using a customized dialysate composition usually requires a continuous measurement of electrolytes and urea in blood. The current practices are spot measurements of blood samples either with blood gas analyzers or in the laboratory, involving considerable personnel effort. Furthermore, the measured values are time delayed and not available in a continuous fashion. In this paper we investigate an in-line concept for continuous monitoring of important blood parameters such as sodium, potassium, calcium and urea concentrations in blood serum using ion-selective electrodes. This concept is evaluated in a preclinical study with human packed red blood cells as a test medium over a period of 7 h. It has been shown that the electrolytes can be well monitored. In addition, we present first measurements with ion-sensitive field-effect transistors in a miniaturized sensor assembly. Therefore, new low-cost electronics for such ion-sensitive field-effect transistors have been developed.
AB - The individualization of dialysis treatment using a customized dialysate composition usually requires a continuous measurement of electrolytes and urea in blood. The current practices are spot measurements of blood samples either with blood gas analyzers or in the laboratory, involving considerable personnel effort. Furthermore, the measured values are time delayed and not available in a continuous fashion. In this paper we investigate an in-line concept for continuous monitoring of important blood parameters such as sodium, potassium, calcium and urea concentrations in blood serum using ion-selective electrodes. This concept is evaluated in a preclinical study with human packed red blood cells as a test medium over a period of 7 h. It has been shown that the electrolytes can be well monitored. In addition, we present first measurements with ion-sensitive field-effect transistors in a miniaturized sensor assembly. Therefore, new low-cost electronics for such ion-sensitive field-effect transistors have been developed.
UR - http://www.scopus.com/inward/record.url?scp=85091113073&partnerID=8YFLogxK
U2 - 10.5194/jsss-9-251-2020
DO - 10.5194/jsss-9-251-2020
M3 - Article
AN - SCOPUS:85091113073
VL - 9
SP - 251
EP - 262
JO - Journal of Sensors and Sensor Systems
JF - Journal of Sensors and Sensor Systems
SN - 2194-8771
IS - 2
ER -