Influence of ionization volume and sample gas flow rate on separation power in gas chromatography-ion mobility spectrometry

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OriginalspracheEnglisch
Aufsatznummer464506
Seitenumfang8
FachzeitschriftJournal of Chromatography A
Jahrgang1713
Frühes Online-Datum13 Nov. 2023
PublikationsstatusVeröffentlicht - 4 Jan. 2024

Abstract

In this work, the influence of the sample gas flow rate and the ionization region volume of an ion mobility spectrometer (IMS) used as a detector in gas chromatography (GC) on GC-IMS peak shape has been investigated. Therefore, a drift tube IMS with a field-switching ion shutter, a defined ionization region volume and an ultra-violet radiation source was used. To identify the influence of the sample gas flow rate entering the ionization region (equals the GC carrier gas flow rate if no further make-up gas is used) and the ionization region volume on peak broadening and signal intensity, different sample volumes as they would elute from a GC were tested at a variety of sample gas flow rates at a given ionization region volume. The results clearly show that for low sample gas flow rates a depletion of sample molecules in the ionization region leads to a significant decrease in effective detector volume but also to reduced signal intensities. Therefore, for optimal performance of a GC-IMS, the optimal operating point of the GC should match the flow range, where the IMS provides the best compromise between signal-to-noise ratio and peak broadening.

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Influence of ionization volume and sample gas flow rate on separation power in gas chromatography-ion mobility spectrometry. / Kobelt, Tim; Lippmann, Martin; Wuttke, Jannik et al.
in: Journal of Chromatography A, Jahrgang 1713, 464506, 04.01.2024.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Kobelt T, Lippmann M, Wuttke J, Wessel H, Zimmermann S. Influence of ionization volume and sample gas flow rate on separation power in gas chromatography-ion mobility spectrometry. Journal of Chromatography A. 2024 Jan 4;1713:464506. Epub 2023 Nov 13. doi: 10.1016/j.chroma.2023.464506
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abstract = "In this work, the influence of the sample gas flow rate and the ionization region volume of an ion mobility spectrometer (IMS) used as a detector in gas chromatography (GC) on GC-IMS peak shape has been investigated. Therefore, a drift tube IMS with a field-switching ion shutter, a defined ionization region volume and an ultra-violet radiation source was used. To identify the influence of the sample gas flow rate entering the ionization region (equals the GC carrier gas flow rate if no further make-up gas is used) and the ionization region volume on peak broadening and signal intensity, different sample volumes as they would elute from a GC were tested at a variety of sample gas flow rates at a given ionization region volume. The results clearly show that for low sample gas flow rates a depletion of sample molecules in the ionization region leads to a significant decrease in effective detector volume but also to reduced signal intensities. Therefore, for optimal performance of a GC-IMS, the optimal operating point of the GC should match the flow range, where the IMS provides the best compromise between signal-to-noise ratio and peak broadening.",
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author = "Tim Kobelt and Martin Lippmann and Jannik Wuttke and Hanno Wessel and Stefan Zimmermann",
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AU - Kobelt, Tim

AU - Lippmann, Martin

AU - Wuttke, Jannik

AU - Wessel, Hanno

AU - Zimmermann, Stefan

N1 - Funding Information: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – SFB/TRR-298-SIIRI – Project-ID 426335750.

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N2 - In this work, the influence of the sample gas flow rate and the ionization region volume of an ion mobility spectrometer (IMS) used as a detector in gas chromatography (GC) on GC-IMS peak shape has been investigated. Therefore, a drift tube IMS with a field-switching ion shutter, a defined ionization region volume and an ultra-violet radiation source was used. To identify the influence of the sample gas flow rate entering the ionization region (equals the GC carrier gas flow rate if no further make-up gas is used) and the ionization region volume on peak broadening and signal intensity, different sample volumes as they would elute from a GC were tested at a variety of sample gas flow rates at a given ionization region volume. The results clearly show that for low sample gas flow rates a depletion of sample molecules in the ionization region leads to a significant decrease in effective detector volume but also to reduced signal intensities. Therefore, for optimal performance of a GC-IMS, the optimal operating point of the GC should match the flow range, where the IMS provides the best compromise between signal-to-noise ratio and peak broadening.

AB - In this work, the influence of the sample gas flow rate and the ionization region volume of an ion mobility spectrometer (IMS) used as a detector in gas chromatography (GC) on GC-IMS peak shape has been investigated. Therefore, a drift tube IMS with a field-switching ion shutter, a defined ionization region volume and an ultra-violet radiation source was used. To identify the influence of the sample gas flow rate entering the ionization region (equals the GC carrier gas flow rate if no further make-up gas is used) and the ionization region volume on peak broadening and signal intensity, different sample volumes as they would elute from a GC were tested at a variety of sample gas flow rates at a given ionization region volume. The results clearly show that for low sample gas flow rates a depletion of sample molecules in the ionization region leads to a significant decrease in effective detector volume but also to reduced signal intensities. Therefore, for optimal performance of a GC-IMS, the optimal operating point of the GC should match the flow range, where the IMS provides the best compromise between signal-to-noise ratio and peak broadening.

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