Details
| Originalsprache | Englisch |
|---|---|
| Titel des Sammelwerks | Small Molecule Medicinal Chemistry |
| Untertitel | Strategies and Technologies |
| Herausgeber/-innen | Werngard Czechtizky, Peter Hamley |
| Herausgeber (Verlag) | Wiley-Blackwell |
| Kapitel | 16 |
| Seiten | 465-501 |
| Seitenumfang | 37 |
| ISBN (elektronisch) | 9781118771723 |
| ISBN (Print) | 9781118771600 |
| Publikationsstatus | Veröffentlicht - 26 Sept. 2015 |
| Extern publiziert | Ja |
Abstract
In vivo imaging has evolved to be one of the most powerful methods to assist modern drug development, and to enable monitoring of disease progression in longitudinal studies by noninvasive methods in living animals. This chapter discusses the general principles and concepts of in vivo imaging and probe design, that are used to visualize the distribution behavior and effects of drug treatment. It provides some selected case studies in the areas of oncology, CNS, and diabetes. Some examples for translating these results into clinical practice are also discussed. The imaging techniques discussed in the chapter are magnetic resonance imaging (MRI), X-ray computer tomography (CT), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and fluorescence-or luminescence-based technologies. Key to success is an early, reliable diagnosis, and allowing clear assessment of the actual disease stage, thus opening up opportunities for therapeutic intervention at an early point in time.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Allgemeine Chemie
- Chemische Verfahrenstechnik (insg.)
- Allgemeine chemische Verfahrenstechnik
- Biochemie, Genetik und Molekularbiologie (insg.)
- Allgemeine Biochemie, Genetik und Molekularbiologie
Ziele für nachhaltige Entwicklung
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Small Molecule Medicinal Chemistry: Strategies and Technologies. Hrsg. / Werngard Czechtizky; Peter Hamley. Wiley-Blackwell, 2015. S. 465-501.
Publikation: Beitrag in Buch/Bericht/Sammelwerk/Konferenzband › Beitrag in Buch/Sammelwerk › Forschung › Peer-Review
}
TY - CHAP
T1 - In Vivo Imaging of Drug Action
AU - Plettenburg, Oliver
AU - Löhn, Matthias
PY - 2015/9/26
Y1 - 2015/9/26
N2 - In vivo imaging has evolved to be one of the most powerful methods to assist modern drug development, and to enable monitoring of disease progression in longitudinal studies by noninvasive methods in living animals. This chapter discusses the general principles and concepts of in vivo imaging and probe design, that are used to visualize the distribution behavior and effects of drug treatment. It provides some selected case studies in the areas of oncology, CNS, and diabetes. Some examples for translating these results into clinical practice are also discussed. The imaging techniques discussed in the chapter are magnetic resonance imaging (MRI), X-ray computer tomography (CT), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and fluorescence-or luminescence-based technologies. Key to success is an early, reliable diagnosis, and allowing clear assessment of the actual disease stage, thus opening up opportunities for therapeutic intervention at an early point in time.
AB - In vivo imaging has evolved to be one of the most powerful methods to assist modern drug development, and to enable monitoring of disease progression in longitudinal studies by noninvasive methods in living animals. This chapter discusses the general principles and concepts of in vivo imaging and probe design, that are used to visualize the distribution behavior and effects of drug treatment. It provides some selected case studies in the areas of oncology, CNS, and diabetes. Some examples for translating these results into clinical practice are also discussed. The imaging techniques discussed in the chapter are magnetic resonance imaging (MRI), X-ray computer tomography (CT), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and fluorescence-or luminescence-based technologies. Key to success is an early, reliable diagnosis, and allowing clear assessment of the actual disease stage, thus opening up opportunities for therapeutic intervention at an early point in time.
KW - Drug action
KW - Fluorescence-based technologies
KW - in vivo imaging
KW - MRI
KW - SPECT
KW - Therapeutic effects
UR - http://www.scopus.com/inward/record.url?scp=84960286044&partnerID=8YFLogxK
U2 - 10.1002/9781118771723.ch16
DO - 10.1002/9781118771723.ch16
M3 - Contribution to book/anthology
AN - SCOPUS:84960286044
SN - 9781118771600
SP - 465
EP - 501
BT - Small Molecule Medicinal Chemistry
A2 - Czechtizky, Werngard
A2 - Hamley, Peter
PB - Wiley-Blackwell
ER -