Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 407-416 |
| Seitenumfang | 10 |
| Fachzeitschrift | Biomedizinische Technik |
| Jahrgang | 58 |
| Ausgabenummer | 5 |
| Frühes Online-Datum | 29 Aug. 2013 |
| Publikationsstatus | Veröffentlicht - 1 Okt. 2013 |
Abstract
Synthetic or biological patch materials used for surgical myocardial reconstruction are often fragile. Therefore, a transient support by degradable magnesium scaffolds can reduce the risk of dilation or rupture of the patch until physiological remodeling has led to a sufficient mechanical durability. However, there is evidence that magnesium implants can influence the growth and physiological behavior of the host's cells and tissue. Hence, we epicardially implanted scaffolds of the magnesium fluoride-coated magnesium alloy LA63 in a swine model to assess biocompatibility and degradation kinetics. Chemical analysis of the pigs' organs revealed no toxic accumulation of magnesium ions in the skeletal muscle, myocardium, liver, kidney, and bone of the pigs 1, 3, and 6 months postimplantation. The implants were surrounded by a fibrous granulation tissue, but no signs of necrosis were histologically evaluable. A sufficiently slow degradation rate of the magnesium alloy scaffold can be demonstrated via micro-computed tomography investigation. We conclude that stabilizing scaffolds of the magnesium fluoride-coated magnesium alloy LA63 can be used for epicardial application because no significant adverse effects to myocardial tissue were noted. Thus, degradable stabilizing scaffolds of this magnesium alloy with a slow degradation rate can extend the indication of innovative biological and synthetic patch materials.
ASJC Scopus Sachgebiete
- Ingenieurwesen (insg.)
- Biomedizintechnik
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in: Biomedizinische Technik, Jahrgang 58, Nr. 5, 01.10.2013, S. 407-416.
Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review
}
TY - JOUR
T1 - In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model
AU - Schilling, Tobias
AU - Brandes, Gudrun
AU - Tudorache, Igor
AU - Cebotari, Serghei
AU - Hilfiker, Andres
AU - Meyer, Tanja
AU - Biskup, Christian
AU - Bauer, Michael
AU - Waldmann, Karl Heinz
AU - Bach, Friedrich Wilhelm
AU - Haverich, Axel
AU - Hassel, Thomas
N1 - Funding Information: Acknowledgments: The project is funded by the German Research Foundation (Collaborative Research Center (SFB) 599/ Project R7). The excellent technical assistance of Christian Klose (Institute of Material Science, Leibniz University Hannover, Hannover, Germany) and Elke Mallon (Institute of Cell Biology in the Center of Anatomy
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Synthetic or biological patch materials used for surgical myocardial reconstruction are often fragile. Therefore, a transient support by degradable magnesium scaffolds can reduce the risk of dilation or rupture of the patch until physiological remodeling has led to a sufficient mechanical durability. However, there is evidence that magnesium implants can influence the growth and physiological behavior of the host's cells and tissue. Hence, we epicardially implanted scaffolds of the magnesium fluoride-coated magnesium alloy LA63 in a swine model to assess biocompatibility and degradation kinetics. Chemical analysis of the pigs' organs revealed no toxic accumulation of magnesium ions in the skeletal muscle, myocardium, liver, kidney, and bone of the pigs 1, 3, and 6 months postimplantation. The implants were surrounded by a fibrous granulation tissue, but no signs of necrosis were histologically evaluable. A sufficiently slow degradation rate of the magnesium alloy scaffold can be demonstrated via micro-computed tomography investigation. We conclude that stabilizing scaffolds of the magnesium fluoride-coated magnesium alloy LA63 can be used for epicardial application because no significant adverse effects to myocardial tissue were noted. Thus, degradable stabilizing scaffolds of this magnesium alloy with a slow degradation rate can extend the indication of innovative biological and synthetic patch materials.
AB - Synthetic or biological patch materials used for surgical myocardial reconstruction are often fragile. Therefore, a transient support by degradable magnesium scaffolds can reduce the risk of dilation or rupture of the patch until physiological remodeling has led to a sufficient mechanical durability. However, there is evidence that magnesium implants can influence the growth and physiological behavior of the host's cells and tissue. Hence, we epicardially implanted scaffolds of the magnesium fluoride-coated magnesium alloy LA63 in a swine model to assess biocompatibility and degradation kinetics. Chemical analysis of the pigs' organs revealed no toxic accumulation of magnesium ions in the skeletal muscle, myocardium, liver, kidney, and bone of the pigs 1, 3, and 6 months postimplantation. The implants were surrounded by a fibrous granulation tissue, but no signs of necrosis were histologically evaluable. A sufficiently slow degradation rate of the magnesium alloy scaffold can be demonstrated via micro-computed tomography investigation. We conclude that stabilizing scaffolds of the magnesium fluoride-coated magnesium alloy LA63 can be used for epicardial application because no significant adverse effects to myocardial tissue were noted. Thus, degradable stabilizing scaffolds of this magnesium alloy with a slow degradation rate can extend the indication of innovative biological and synthetic patch materials.
KW - Biocompatibility
KW - Corrosion
KW - Fluoride coating
KW - Patch
KW - Reconstruction
UR - http://www.scopus.com/inward/record.url?scp=84896526774&partnerID=8YFLogxK
U2 - 10.1515/bmt-2012-0047
DO - 10.1515/bmt-2012-0047
M3 - Review article
C2 - 23989110
AN - SCOPUS:84896526774
VL - 58
SP - 407
EP - 416
JO - Biomedizinische Technik
JF - Biomedizinische Technik
SN - 0013-5585
IS - 5
ER -