In vitro production of cyclic peptides

Publikation: Schutzrecht/Patent › Patent

Erfinder/-innen

  • Wael Houssen Ibrahim (Erfinder*in)
  • Marcel Jaspars (Erfinder*in)
  • Margaret Smith (Erfinder*in)
  • James Naismith (Erfinder*in)
  • Jesko Koehnke (Erfinder*in)
  • Andrew Bent (Erfinder*in)
  • Nicholas Westwood (Erfinder*in)

Organisationseinheiten

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Details

OriginalspracheEnglisch
Veröffentlichungsnummer (amtliches Aktenzeichen)AU2013282973A1
IPCC07K7/64,G01N33/53
Prioritätsdatum29 Juni 2012
Anmeldedatum28 Juni 2013
PublikationsstatusVeröffentlicht - 5 Feb. 2015

Abstract

This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

Zitieren

In vitro production of cyclic peptides. / Ibrahim, Wael Houssen (Erfinder*in); Jaspars, Marcel (Erfinder*in); Smith, Margaret (Erfinder*in) et al.
Patent Nr.: AU2013282973A1. Feb. 05, 2015.

Publikation: Schutzrecht/Patent › Patent

Ibrahim, WH, Jaspars, M, Smith, M, Naismith, J, Koehnke, J, Bent, A & Westwood, N Feb.. 05 2015, In vitro production of cyclic peptides, Patent Nr. AU2013282973A1. <https://worldwide.espacenet.com/patent/search?q=pn%3DAU2013282973A1>
Ibrahim, W. H., Jaspars, M., Smith, M., Naismith, J., Koehnke, J., Bent, A., & Westwood, N. (2015). In vitro production of cyclic peptides. (Patent Nr. AU2013282973A1). https://worldwide.espacenet.com/patent/search?q=pn%3DAU2013282973A1
Ibrahim WH, Jaspars M, Smith M, Naismith J, Koehnke J, Bent A et al., Erfinder/-innen. In vitro production of cyclic peptides. AU2013282973A1. 2015 Feb 5.
Ibrahim, Wael Houssen (Erfinder*in) ; Jaspars, Marcel (Erfinder*in) ; Smith, Margaret (Erfinder*in) et al. / In vitro production of cyclic peptides. Patent Nr.: AU2013282973A1. Feb. 05, 2015.
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title = "In vitro production of cyclic peptides",
abstract = "This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.",
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TY - PAT

T1 - In vitro production of cyclic peptides

AU - Ibrahim, Wael Houssen

AU - Jaspars, Marcel

AU - Smith, Margaret

AU - Naismith, James

AU - Koehnke, Jesko

AU - Bent, Andrew

AU - Westwood, Nicholas

PY - 2015/2/5

Y1 - 2015/2/5

N2 - This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

AB - This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

M3 - Patent

M1 - AU2013282973A1

Y2 - 2013/06/28

ER -