TY - JOUR

T1 - In vitro corrosion of ZEK100 plates in Hank's Balanced Salt Solution

AU - Waizy, Hazibullah

AU - Weizbauer, Andreas

AU - Modrejewski, Christian

AU - Witte, Frank

AU - Windhagen, Henning

AU - Lucas, Arne

AU - Kieke, Marc

AU - Denkena, Berend

AU - Behrens, Peter

AU - Meyer-Lindenberg, Andrea

AU - Bach, Friedrich Wilhelm

AU - Thorey, Fritz

N1 - Funding information: The authors gratefully acknowledge the financial support given by German research society (DFG) within the collaborative research project (SFB 599). We thank Markus Badenhop for excellent technical support. We thank Christopher Müller for the design of Figure 1 and Hendrik Wardenga for creating Figure 2.

PY - 2012/3/13

Y1 - 2012/3/13

N2 - Background: In recent years magnesium alloys have been intensively investigated as potential resorbable materials with appropriate mechanical and corrosion properties. Particularly in orthopedic research magnesium is interesting because of its mechanical properties close to those of natural bone, the prevention of both stress shielding and removal of the implant after surgery.Methods: ZEK100 plates were examined in this in vitro study with Hank's Balanced Salt Solution under physiological conditions with a constant laminar flow rate. After 14, 28 and 42 days of immersion the ZEK100 plates were mechanically tested via four point bending test. The surfaces of the immersed specimens were characterized by SEM, EDX and XRD.Results: The four point bending test displayed an increased bending strength after 6 weeks immersion compared to the 2 week group and 4 week group. The characterization of the surface revealed the presence of high amounts of O, P and Ca on the surface and small Mg content. This indicates the precipitation of calcium phosphates with low solubility on the surface of the ZEK100 plates.Conclusions: The results of the present in vitro study indicate that ZEK100 is a potential candidate for degradable orthopedic implants. Further investigations are needed to examine the degradation behavior.

AB - Background: In recent years magnesium alloys have been intensively investigated as potential resorbable materials with appropriate mechanical and corrosion properties. Particularly in orthopedic research magnesium is interesting because of its mechanical properties close to those of natural bone, the prevention of both stress shielding and removal of the implant after surgery.Methods: ZEK100 plates were examined in this in vitro study with Hank's Balanced Salt Solution under physiological conditions with a constant laminar flow rate. After 14, 28 and 42 days of immersion the ZEK100 plates were mechanically tested via four point bending test. The surfaces of the immersed specimens were characterized by SEM, EDX and XRD.Results: The four point bending test displayed an increased bending strength after 6 weeks immersion compared to the 2 week group and 4 week group. The characterization of the surface revealed the presence of high amounts of O, P and Ca on the surface and small Mg content. This indicates the precipitation of calcium phosphates with low solubility on the surface of the ZEK100 plates.Conclusions: The results of the present in vitro study indicate that ZEK100 is a potential candidate for degradable orthopedic implants. Further investigations are needed to examine the degradation behavior.

KW - Corrosion

KW - In vitro study

KW - Magnesium alloy

KW - Plates

UR - http://www.scopus.com/inward/record.url?scp=84857943420&partnerID=8YFLogxK

U2 - 10.1186/1475-925X-11-12

DO - 10.1186/1475-925X-11-12

M3 - Article

C2 - 22413949

AN - SCOPUS:84857943420

VL - 11

JO - Biomedical engineering online

JF - Biomedical engineering online

SN - 1475-925X

M1 - 12

ER -