Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 231-236 |
| Seitenumfang | 6 |
| Fachzeitschrift | European journal of mineralogy |
| Jahrgang | 31 |
| Ausgabenummer | 2 |
| Frühes Online-Datum | 25 Jan. 2019 |
| Publikationsstatus | Veröffentlicht - 7 Juni 2019 |
| Extern publiziert | Ja |
Abstract
Biomedical applications of calcium carbonate minerals have been receiving an increasing amount of attention. With a simple chemical composition, low production cost, and ease to produce in large quantities, this non-toxic (bio)mineral has been used preferentially in the pharmaceutical industry as a diluent, bulking or coating agent. Recently, novel products have been developed and amorphous calcium carbonate was successfully used as a hybrid carrier for drugs, proteins and genes. It is obvious that any impurities might have adverse effects in any of the aforementioned applications. However, the synthesis of impurity-free amorphous calcium carbonate often proves to be challenging due to its instability and rapid transformation to crystalline phases. Herein, we describe a novel, simple and scalable protocol for the synthesis of such impurity-free amorphous calcium carbonate nanoparticles that is potentially invaluable for critical health applications, improving the applicability of amorphous calcium carbonates in pharmaceutical and medical domains.
ASJC Scopus Sachgebiete
- Erdkunde und Planetologie (insg.)
- Geochemie und Petrologie
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
in: European journal of mineralogy, Jahrgang 31, Nr. 2, 07.06.2019, S. 231-236.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Impurity-free amorphous calcium carbonate, a preferential material for pharmaceutical and medical applications
AU - Avaro, Jonathan Thomas
AU - Ruiz-Agudo, Cristina
AU - Landwehr, Eliane
AU - Hauser, Karin
AU - Gebauer, Denis
N1 - Funding Information: Acknowledgements: The authors thank the Deutsche Forschungsgemeinschaft (SFB1214, A2 and A7) and the Zukunftskolleg of the University of Konstanz for support.
PY - 2019/6/7
Y1 - 2019/6/7
N2 - Biomedical applications of calcium carbonate minerals have been receiving an increasing amount of attention. With a simple chemical composition, low production cost, and ease to produce in large quantities, this non-toxic (bio)mineral has been used preferentially in the pharmaceutical industry as a diluent, bulking or coating agent. Recently, novel products have been developed and amorphous calcium carbonate was successfully used as a hybrid carrier for drugs, proteins and genes. It is obvious that any impurities might have adverse effects in any of the aforementioned applications. However, the synthesis of impurity-free amorphous calcium carbonate often proves to be challenging due to its instability and rapid transformation to crystalline phases. Herein, we describe a novel, simple and scalable protocol for the synthesis of such impurity-free amorphous calcium carbonate nanoparticles that is potentially invaluable for critical health applications, improving the applicability of amorphous calcium carbonates in pharmaceutical and medical domains.
AB - Biomedical applications of calcium carbonate minerals have been receiving an increasing amount of attention. With a simple chemical composition, low production cost, and ease to produce in large quantities, this non-toxic (bio)mineral has been used preferentially in the pharmaceutical industry as a diluent, bulking or coating agent. Recently, novel products have been developed and amorphous calcium carbonate was successfully used as a hybrid carrier for drugs, proteins and genes. It is obvious that any impurities might have adverse effects in any of the aforementioned applications. However, the synthesis of impurity-free amorphous calcium carbonate often proves to be challenging due to its instability and rapid transformation to crystalline phases. Herein, we describe a novel, simple and scalable protocol for the synthesis of such impurity-free amorphous calcium carbonate nanoparticles that is potentially invaluable for critical health applications, improving the applicability of amorphous calcium carbonates in pharmaceutical and medical domains.
KW - Amorphous calcium carbonate
KW - Drug delivery
KW - Impurity-free
KW - Nanoparticles
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=85066893693&partnerID=8YFLogxK
U2 - 10.1127/EJM/2019/0031-2831
DO - 10.1127/EJM/2019/0031-2831
M3 - Article
VL - 31
SP - 231
EP - 236
JO - European journal of mineralogy
JF - European journal of mineralogy
SN - 0935-1221
IS - 2
ER -