Improved synthesis of the northern hemisphere of epothilone A by a sharpless asymmetric dihydroxylation

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OriginalspracheEnglisch
Seiten (von - bis)7765-7768
Seitenumfang4
FachzeitschriftTetrahedron letters
Jahrgang40
Ausgabenummer44
PublikationsstatusVeröffentlicht - 29 Okt. 1999

Abstract

An improved synthesis of the northern hemisphere of epothilone A is described. This approach utilizes the Sharpless asymmetric dihydroxylation of 5-hexen-2-one (allyl acetone) to generate the precursor for the Wittig reaction and the subsequent ring closing metathesis reaction (RCM). This strategy allows to generate precursor 13 as both enantiomers from ready available starting material in a very efficient manner.

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Improved synthesis of the northern hemisphere of epothilone A by a sharpless asymmetric dihydroxylation. / Quitschalle, Monika; Kalesse, Markus.
in: Tetrahedron letters, Jahrgang 40, Nr. 44, 29.10.1999, S. 7765-7768.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

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abstract = "An improved synthesis of the northern hemisphere of epothilone A is described. This approach utilizes the Sharpless asymmetric dihydroxylation of 5-hexen-2-one (allyl acetone) to generate the precursor for the Wittig reaction and the subsequent ring closing metathesis reaction (RCM). This strategy allows to generate precursor 13 as both enantiomers from ready available starting material in a very efficient manner.",
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AU - Kalesse, Markus

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