TY - JOUR

T1 - Implant-based direction of magnetic nanoporous silica nanoparticles

T2 - influence of macrophage depletion and infection

AU - Reifenrath, Janin

AU - Janßen, Hilke Catherina

AU - Warwas, Dawid Peter

AU - Kietzmann, Manfred

AU - Behrens, Peter

AU - Willbold, Elmar

AU - Fedchenko, Mykola

AU - Angrisani, Nina

N1 - Funding Information: This work was supported by the German Research Foundation as part of the project “Implant-Directed Magnetic Drug Targeting: Antibiotic therapy of peri-implant infections”, project number: 280642759 . The authors thank Diana Strauch, Mattias Reebmann and Merle Kempfert for excellent technical support. They also thank Silva Holtfreter (University Medicine Greifswald) and Siouxsie Wiles (University of Auckland) for providing the used S. aureus strain. Further thanks go to Mandy Jahns for performing nitrogen physisorption measurements.

PY - 2020/11

Y1 - 2020/11

N2 - Implant associated infections are still key problem in surgery. In the present study, the combination of a magnetic implant with administered magnetic nanoporous silica nanoparticles as potential drug carriers was examined in mice in dependence of local infection and macrophages as influencing factors. Four groups of mice (with and without implant infection and with and without macrophage depletion) received a magnet on the left and a titanium control on the right hind leg. Then, fluorescent nanoparticles were administered and particle accumulations at implant surfaces and in inner organs as well as local tissue reactions were analyzed. Magnetic nanoparticles could be found at the surfaces of magnetic implants in different amounts depending on the treatment groups and only rarely at titanium surfaces. Different interactions of magnetic implants, particles, infection and surrounding tissues occurred. The general principle of targeted accumulation of magnetic nanoparticles could be proven.

AB - Implant associated infections are still key problem in surgery. In the present study, the combination of a magnetic implant with administered magnetic nanoporous silica nanoparticles as potential drug carriers was examined in mice in dependence of local infection and macrophages as influencing factors. Four groups of mice (with and without implant infection and with and without macrophage depletion) received a magnet on the left and a titanium control on the right hind leg. Then, fluorescent nanoparticles were administered and particle accumulations at implant surfaces and in inner organs as well as local tissue reactions were analyzed. Magnetic nanoparticles could be found at the surfaces of magnetic implants in different amounts depending on the treatment groups and only rarely at titanium surfaces. Different interactions of magnetic implants, particles, infection and surrounding tissues occurred. The general principle of targeted accumulation of magnetic nanoparticles could be proven.

KW - Accumulation

KW - Drug targeting

KW - Implant-associated infection

KW - Magnetic implant

UR - http://www.scopus.com/inward/record.url?scp=85091061184&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2020.102289

DO - 10.1016/j.nano.2020.102289

M3 - Article

C2 - 32861030

AN - SCOPUS:85091061184

VL - 30

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

M1 - 102289

ER -