Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 485-500 |
| Seitenumfang | 16 |
| Fachzeitschrift | Beneficial microbes |
| Jahrgang | 7 |
| Ausgabenummer | 4 |
| Publikationsstatus | Veröffentlicht - 2016 |
Abstract
It is now generally accepted that the human body exists in close synergy with the gut microbiome and that this cross-talk plays an essential role in human health and disease. One facet from the many interactions between the microbiome and the immune system is the induction of natural antibodies to commensal bacterial glycans, such as blood group antigens, the alpha-Gal epitope or the Thomsen-Friedenreich (TFa) antigen. Since we have observed that certain species of the commensal genus Bacteroides express the TFa antigen, we examined whether the oral dietary supplementation of a pasteurised Bacteroides xylanisolvens strain might be able to enhance the level of natural anti-TFa antibodies in healthy adults. The data obtained from a double-blind, placebo-controlled study involving 140 healthy volunteers and lasting 8 weeks revealed that the oral uptake of this strain was indeed able to increase the level of TFa-specific immunoglobulin M serum antibodies. The effect was dose-dependent but remained - at any doses - within the physiological range determined before intervention. Furthermore, the effect reverted after stopping the intake. The results support the idea of the microbiome inducing the generation of systemic antigen-specific antibodies against sugar epitopes. They also demonstrate the possibility to modulate essential regulatory or defence processes through dietary supplementation of selected commensal bacteria with the aim to assist human health.
ASJC Scopus Sachgebiete
- Immunologie und Mikrobiologie (insg.)
- Mikrobiologie
- Medizin (insg.)
- Mikrobiologie (medizinisch)
Ziele für nachhaltige Entwicklung
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
in: Beneficial microbes, Jahrgang 7, Nr. 4, 2016, S. 485-500.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Impact of oral consumption of heat-treated Bacteroides xylanisolvens DSM 23964 on the level of natural TF-α-specific antibodies in human adults
AU - Ulsemer, P.
AU - Toutounian, K.
AU - Kressel, Gaby
AU - Goletz, C.
AU - Schmidt, J.
AU - Karsten, U.
AU - Hahn, Andreas
AU - Goletz, S.
N1 - Publisher Copyright: © 2016 Wageningen Academic Publishers. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2016
Y1 - 2016
N2 - It is now generally accepted that the human body exists in close synergy with the gut microbiome and that this cross-talk plays an essential role in human health and disease. One facet from the many interactions between the microbiome and the immune system is the induction of natural antibodies to commensal bacterial glycans, such as blood group antigens, the alpha-Gal epitope or the Thomsen-Friedenreich (TFa) antigen. Since we have observed that certain species of the commensal genus Bacteroides express the TFa antigen, we examined whether the oral dietary supplementation of a pasteurised Bacteroides xylanisolvens strain might be able to enhance the level of natural anti-TFa antibodies in healthy adults. The data obtained from a double-blind, placebo-controlled study involving 140 healthy volunteers and lasting 8 weeks revealed that the oral uptake of this strain was indeed able to increase the level of TFa-specific immunoglobulin M serum antibodies. The effect was dose-dependent but remained - at any doses - within the physiological range determined before intervention. Furthermore, the effect reverted after stopping the intake. The results support the idea of the microbiome inducing the generation of systemic antigen-specific antibodies against sugar epitopes. They also demonstrate the possibility to modulate essential regulatory or defence processes through dietary supplementation of selected commensal bacteria with the aim to assist human health.
AB - It is now generally accepted that the human body exists in close synergy with the gut microbiome and that this cross-talk plays an essential role in human health and disease. One facet from the many interactions between the microbiome and the immune system is the induction of natural antibodies to commensal bacterial glycans, such as blood group antigens, the alpha-Gal epitope or the Thomsen-Friedenreich (TFa) antigen. Since we have observed that certain species of the commensal genus Bacteroides express the TFa antigen, we examined whether the oral dietary supplementation of a pasteurised Bacteroides xylanisolvens strain might be able to enhance the level of natural anti-TFa antibodies in healthy adults. The data obtained from a double-blind, placebo-controlled study involving 140 healthy volunteers and lasting 8 weeks revealed that the oral uptake of this strain was indeed able to increase the level of TFa-specific immunoglobulin M serum antibodies. The effect was dose-dependent but remained - at any doses - within the physiological range determined before intervention. Furthermore, the effect reverted after stopping the intake. The results support the idea of the microbiome inducing the generation of systemic antigen-specific antibodies against sugar epitopes. They also demonstrate the possibility to modulate essential regulatory or defence processes through dietary supplementation of selected commensal bacteria with the aim to assist human health.
KW - Bacteroides xylanisolvens
KW - Immune response
KW - Microbiome
KW - TFa-specific antibodies
KW - Thomsen-Friedenreich antigen
UR - http://www.scopus.com/inward/record.url?scp=84988909614&partnerID=8YFLogxK
U2 - 10.3920/bm2015.0143
DO - 10.3920/bm2015.0143
M3 - Article
VL - 7
SP - 485
EP - 500
JO - Beneficial microbes
JF - Beneficial microbes
SN - 1876-2883
IS - 4
ER -