Impact of nutrition on short-term exercise-induced sirtuin regulation: Vegans differ from omnivores and LACTO-OVO vegetarians

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Arne Björn Potthast
  • Josefine Nebl
  • Paulina Wasserfurth
  • S. Haufe
  • J. Eigendorf
  • Andreas Hahn
  • Anibh Das
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Aufsatznummer1004
FachzeitschriftNUTRIENTS
Jahrgang12
Ausgabenummer4
PublikationsstatusVeröffentlicht - 5 Apr. 2020

Abstract

Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3– SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1, SIRT3, and SIRT5 enzyme activities increased during exercise in omnivores and lacto-ovo vegetarians, commensurate with increased energy demand. However, activities decreased in vegans. Malondialdehyde as a surrogate marker of oxidative stress inversely correlated with sirtuin activities and was elevated in vegans after exercise compared to both other groups. A significant negative correlation of all sirtuins with the intake of the antioxidative substances, ascorbate and tocopherol, was found. In vegan participants, increased oxidative stress despite higher amounts of the antioxidative substances in the diet was observed after exercise.

ASJC Scopus Sachgebiete

Zitieren

Impact of nutrition on short-term exercise-induced sirtuin regulation: Vegans differ from omnivores and LACTO-OVO vegetarians. / Potthast, Arne Björn; Nebl, Josefine; Wasserfurth, Paulina et al.
in: NUTRIENTS, Jahrgang 12, Nr. 4, 1004, 05.04.2020.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Potthast AB, Nebl J, Wasserfurth P, Haufe S, Eigendorf J, Hahn A et al. Impact of nutrition on short-term exercise-induced sirtuin regulation: Vegans differ from omnivores and LACTO-OVO vegetarians. NUTRIENTS. 2020 Apr 5;12(4):1004. doi: 10.3390/nu12041004
Potthast, Arne Björn ; Nebl, Josefine ; Wasserfurth, Paulina et al. / Impact of nutrition on short-term exercise-induced sirtuin regulation : Vegans differ from omnivores and LACTO-OVO vegetarians. in: NUTRIENTS. 2020 ; Jahrgang 12, Nr. 4.
Download
@article{0405bfe5e9af44cfa9803015d958b7bb,
title = "Impact of nutrition on short-term exercise-induced sirtuin regulation: Vegans differ from omnivores and LACTO-OVO vegetarians",
abstract = "Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3– SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1, SIRT3, and SIRT5 enzyme activities increased during exercise in omnivores and lacto-ovo vegetarians, commensurate with increased energy demand. However, activities decreased in vegans. Malondialdehyde as a surrogate marker of oxidative stress inversely correlated with sirtuin activities and was elevated in vegans after exercise compared to both other groups. A significant negative correlation of all sirtuins with the intake of the antioxidative substances, ascorbate and tocopherol, was found. In vegan participants, increased oxidative stress despite higher amounts of the antioxidative substances in the diet was observed after exercise.",
keywords = "Endurance athletes, Exercise, Metabolic regulation, Sirtuins, Vegan, Vegetarian",
author = "Potthast, {Arne Bj{\"o}rn} and Josefine Nebl and Paulina Wasserfurth and S. Haufe and J. Eigendorf and Andreas Hahn and Anibh Das",
note = "Funding information: Financial funding for sirtuin analyses by Vitaflo Int. Ltd.",
year = "2020",
month = apr,
day = "5",
doi = "10.3390/nu12041004",
language = "English",
volume = "12",
journal = "NUTRIENTS",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "4",

}

Download

TY - JOUR

T1 - Impact of nutrition on short-term exercise-induced sirtuin regulation

T2 - Vegans differ from omnivores and LACTO-OVO vegetarians

AU - Potthast, Arne Björn

AU - Nebl, Josefine

AU - Wasserfurth, Paulina

AU - Haufe, S.

AU - Eigendorf, J.

AU - Hahn, Andreas

AU - Das, Anibh

N1 - Funding information: Financial funding for sirtuin analyses by Vitaflo Int. Ltd.

PY - 2020/4/5

Y1 - 2020/4/5

N2 - Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3– SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1, SIRT3, and SIRT5 enzyme activities increased during exercise in omnivores and lacto-ovo vegetarians, commensurate with increased energy demand. However, activities decreased in vegans. Malondialdehyde as a surrogate marker of oxidative stress inversely correlated with sirtuin activities and was elevated in vegans after exercise compared to both other groups. A significant negative correlation of all sirtuins with the intake of the antioxidative substances, ascorbate and tocopherol, was found. In vegan participants, increased oxidative stress despite higher amounts of the antioxidative substances in the diet was observed after exercise.

AB - Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3– SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1, SIRT3, and SIRT5 enzyme activities increased during exercise in omnivores and lacto-ovo vegetarians, commensurate with increased energy demand. However, activities decreased in vegans. Malondialdehyde as a surrogate marker of oxidative stress inversely correlated with sirtuin activities and was elevated in vegans after exercise compared to both other groups. A significant negative correlation of all sirtuins with the intake of the antioxidative substances, ascorbate and tocopherol, was found. In vegan participants, increased oxidative stress despite higher amounts of the antioxidative substances in the diet was observed after exercise.

KW - Endurance athletes

KW - Exercise

KW - Metabolic regulation

KW - Sirtuins

KW - Vegan

KW - Vegetarian

UR - http://www.scopus.com/inward/record.url?scp=85083023168&partnerID=8YFLogxK

U2 - 10.3390/nu12041004

DO - 10.3390/nu12041004

M3 - Article

C2 - 32260570

VL - 12

JO - NUTRIENTS

JF - NUTRIENTS

SN - 2072-6643

IS - 4

M1 - 1004

ER -

Von denselben Autoren