Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 531-539 |
| Seitenumfang | 9 |
| Fachzeitschrift | Journal of Cardiovascular Translational Research |
| Jahrgang | 13 |
| Ausgabenummer | 4 |
| Publikationsstatus | Veröffentlicht - Aug. 2020 |
| Extern publiziert | Ja |
Abstract
Cardiac output during exercise increases by as much as fivefold in the untrained man, and by as much as eightfold in the elite athlete. Increasing venous return is a critical but much overlooked component of the physiological response to exercise. Cardiac disorders such as constrictive pericarditis, restrictive cardiomyopathy and pulmonary hypertension are recognised to impair preload and cause exercise limitation; however, the effects of peripheral venous obstruction on cardiac function have not been well described. This manuscript will discuss how obstruction of the iliocaval venous outflow can lead to impairment in exercise tolerance, how such obstructions may be diagnosed, the potential implications of chronic obstructions on sympathetic nervous system activation, and relevance of venous compression syndromes in heart failure with preserved ejection fraction.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularmedizin
- Biochemie, Genetik und Molekularbiologie (insg.)
- Genetik
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Pharmazeutische Wissenschaften
- Medizin (insg.)
- Kardiologie und kardiovaskuläre Medizin
- Medizin (insg.)
- Genetik (klinisch)
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in: Journal of Cardiovascular Translational Research, Jahrgang 13, Nr. 4, 08.2020, S. 531-539.
Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review
}
TY - JOUR
T1 - Iliocaval Venous Obstruction, Cardiac Preload Reserve and Exercise Limitation
AU - Morris, Rachael I.
AU - Sobotka, Paul A.
AU - Balmforth, Peter K.
AU - Stöhr, Eric J.
AU - McDonnell, Barry J.
AU - Spencer, Darren
AU - O’Sullivan, Gerard J.
AU - Black, Stephen A.
PY - 2020/8
Y1 - 2020/8
N2 - Cardiac output during exercise increases by as much as fivefold in the untrained man, and by as much as eightfold in the elite athlete. Increasing venous return is a critical but much overlooked component of the physiological response to exercise. Cardiac disorders such as constrictive pericarditis, restrictive cardiomyopathy and pulmonary hypertension are recognised to impair preload and cause exercise limitation; however, the effects of peripheral venous obstruction on cardiac function have not been well described. This manuscript will discuss how obstruction of the iliocaval venous outflow can lead to impairment in exercise tolerance, how such obstructions may be diagnosed, the potential implications of chronic obstructions on sympathetic nervous system activation, and relevance of venous compression syndromes in heart failure with preserved ejection fraction.
AB - Cardiac output during exercise increases by as much as fivefold in the untrained man, and by as much as eightfold in the elite athlete. Increasing venous return is a critical but much overlooked component of the physiological response to exercise. Cardiac disorders such as constrictive pericarditis, restrictive cardiomyopathy and pulmonary hypertension are recognised to impair preload and cause exercise limitation; however, the effects of peripheral venous obstruction on cardiac function have not been well described. This manuscript will discuss how obstruction of the iliocaval venous outflow can lead to impairment in exercise tolerance, how such obstructions may be diagnosed, the potential implications of chronic obstructions on sympathetic nervous system activation, and relevance of venous compression syndromes in heart failure with preserved ejection fraction.
KW - Exercise capacity
KW - Iliac venous disease
KW - Preload
KW - Venous obstruction
KW - Venous stenosis
UR - http://www.scopus.com/inward/record.url?scp=85079456925&partnerID=8YFLogxK
U2 - 10.1007/s12265-020-09963-w
DO - 10.1007/s12265-020-09963-w
M3 - Review article
C2 - 32040765
AN - SCOPUS:85079456925
VL - 13
SP - 531
EP - 539
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
SN - 1937-5387
IS - 4
ER -