Hydrazine clubbed 1,3-thiazoles as potent urease inhibitors: design, synthesis and molecular docking studies

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Pervaiz Ali Channar
  • Aamer Saeed
  • Saira Afzal
  • Dilawar Hussain
  • Markus Kalesse
  • Syeda Aaliya Shehzadi
  • Jamshed Iqbal

Organisationseinheiten

Externe Organisationen

  • Quaid-I-Azam University
  • COMSATS Institute of Information Technology Lahore
  • International Islamic University Islamabad
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Details

OriginalspracheEnglisch
Seitenumfang13
FachzeitschriftMolecular diversity
Jahrgang25
Ausgabenummer2
Frühes Online-Datum24 Feb. 2020
PublikationsstatusVeröffentlicht - Mai 2021

Abstract

Abstract: Synthesis of a novel series of hydrazine clubbed 1,3-thiazoles (5a–m) has been described by reacting hydrazine-1-carbothioamides (3a–k) with α-chloro- or bromo-acetophenones (4a–d) in refluxing ethanol in good to excellent yields (65–86%). Structural confirmation was based upon spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR and mass spectrometry. The biological application of these motifs has been demonstrated in terms of their strong urease inhibition activity. The results of in vitro study revealed that all the compounds are the potent inhibitors of urease. The IC 50 (ranging in between 110 and 440 nM) values were higher as compared to that of standard, i.e., thiourea (IC 50 = 490 ± 10 nM). The synthesized compounds were docked at the active sites of the Jack bean urease enzyme in order to explore the possible binding interactions of enzyme–ligand complexes; the results reinforced the in vitro biological activity results. Graphic abstract: [Figure not available: see fulltext.].

ASJC Scopus Sachgebiete

Zitieren

Hydrazine clubbed 1,3-thiazoles as potent urease inhibitors: design, synthesis and molecular docking studies. / Channar, Pervaiz Ali; Saeed, Aamer; Afzal, Saira et al.
in: Molecular diversity, Jahrgang 25, Nr. 2, 05.2021.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Channar PA, Saeed A, Afzal S, Hussain D, Kalesse M, Shehzadi SA et al. Hydrazine clubbed 1,3-thiazoles as potent urease inhibitors: design, synthesis and molecular docking studies. Molecular diversity. 2021 Mai;25(2). Epub 2020 Feb 24. doi: 10.1007/s11030-020-10057-7
Channar, Pervaiz Ali ; Saeed, Aamer ; Afzal, Saira et al. / Hydrazine clubbed 1,3-thiazoles as potent urease inhibitors: design, synthesis and molecular docking studies. in: Molecular diversity. 2021 ; Jahrgang 25, Nr. 2.
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abstract = "Abstract: Synthesis of a novel series of hydrazine clubbed 1,3-thiazoles (5a–m) has been described by reacting hydrazine-1-carbothioamides (3a–k) with α-chloro- or bromo-acetophenones (4a–d) in refluxing ethanol in good to excellent yields (65–86%). Structural confirmation was based upon spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR and mass spectrometry. The biological application of these motifs has been demonstrated in terms of their strong urease inhibition activity. The results of in vitro study revealed that all the compounds are the potent inhibitors of urease. The IC 50 (ranging in between 110 and 440 nM) values were higher as compared to that of standard, i.e., thiourea (IC 50 = 490 ± 10 nM). The synthesized compounds were docked at the active sites of the Jack bean urease enzyme in order to explore the possible binding interactions of enzyme–ligand complexes; the results reinforced the in vitro biological activity results. Graphic abstract: [Figure not available: see fulltext.]. ",
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AU - Channar, Pervaiz Ali

AU - Saeed, Aamer

AU - Afzal, Saira

AU - Hussain, Dilawar

AU - Kalesse, Markus

AU - Shehzadi, Syeda Aaliya

AU - Iqbal, Jamshed

N1 - Funding information: A.S. is grateful to Alexander von Humboldt Foundation Germany, for a Gerog Forster Post-doctoral fellowship. J.I. is thankful to the Higher Education Commission of Pakistan for the financial support through Project No. Ph-V-MG-3/Peridot/R&D/HEC/2019.

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N2 - Abstract: Synthesis of a novel series of hydrazine clubbed 1,3-thiazoles (5a–m) has been described by reacting hydrazine-1-carbothioamides (3a–k) with α-chloro- or bromo-acetophenones (4a–d) in refluxing ethanol in good to excellent yields (65–86%). Structural confirmation was based upon spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR and mass spectrometry. The biological application of these motifs has been demonstrated in terms of their strong urease inhibition activity. The results of in vitro study revealed that all the compounds are the potent inhibitors of urease. The IC 50 (ranging in between 110 and 440 nM) values were higher as compared to that of standard, i.e., thiourea (IC 50 = 490 ± 10 nM). The synthesized compounds were docked at the active sites of the Jack bean urease enzyme in order to explore the possible binding interactions of enzyme–ligand complexes; the results reinforced the in vitro biological activity results. Graphic abstract: [Figure not available: see fulltext.].

AB - Abstract: Synthesis of a novel series of hydrazine clubbed 1,3-thiazoles (5a–m) has been described by reacting hydrazine-1-carbothioamides (3a–k) with α-chloro- or bromo-acetophenones (4a–d) in refluxing ethanol in good to excellent yields (65–86%). Structural confirmation was based upon spectroscopic techniques such as 1H-NMR, 13C-NMR, FT-IR and mass spectrometry. The biological application of these motifs has been demonstrated in terms of their strong urease inhibition activity. The results of in vitro study revealed that all the compounds are the potent inhibitors of urease. The IC 50 (ranging in between 110 and 440 nM) values were higher as compared to that of standard, i.e., thiourea (IC 50 = 490 ± 10 nM). The synthesized compounds were docked at the active sites of the Jack bean urease enzyme in order to explore the possible binding interactions of enzyme–ligand complexes; the results reinforced the in vitro biological activity results. Graphic abstract: [Figure not available: see fulltext.].

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