Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 467 |
| Fachzeitschrift | Water, Air, and Soil Pollution |
| Jahrgang | 234 |
| Ausgabenummer | 7 |
| Frühes Online-Datum | 11 Juli 2023 |
| Publikationsstatus | Veröffentlicht - Juli 2023 |
Abstract
Antimicrobial resistance is raging, but large size of India limits comprehensive exploration. This demands a sample like sewage, which could represent a large population and is often reported to harbor resistant microbes. Here, we did pan-India sewage sampling and studied the antibiotic resistance pattern in the microbial community. We used culture-based antibiotic susceptibility assays and estimated the level of antibiotics present at each site. We found high antibiotic resistance across all cities of India with more diversity of resistance profiles in bigger cities as compared to smaller ones. Bacillus and Pseudomonas were the most common, predominant resistant genera across Indian cities and many sites harbored multi-drug resistant phenotypes. Antibiotic concentrations were below recommended limits at all sites and thus high resistance is not likely caused solely due to antibiotics. Sewage proved to be a good representative for rapidly studying antibiotic resistance in a big country and for similar epidemiological strides.
ASJC Scopus Sachgebiete
- Umweltwissenschaften (insg.)
- Environmental engineering
- Umweltwissenschaften (insg.)
- Umweltchemie
- Umweltwissenschaften (insg.)
- Ökologische Modellierung
- Umweltwissenschaften (insg.)
- Gewässerkunde und -technologie
- Umweltwissenschaften (insg.)
- Umweltverschmutzung
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in: Water, Air, and Soil Pollution, Jahrgang 234, Nr. 7, 467, 07.2023.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - High Antibiotic Resistance in Indian Sewage Shows Distinct Trends and might be Disjoint from in-situ Antibiotic Levels
AU - Singh, Kumar Siddharth
AU - Keer, Abhishek
AU - Zed, Aakib
AU - Jasmeen, Rahila
AU - Mishra, Kamini
AU - Mourya, Neha
AU - Paul, Dhiraj
AU - Dhotre, Dhiraj
AU - Shouche, Yogesh
N1 - Funding Information: Commissioners of Municipal corporations of Ahmedabad, Bengaluru, Bikaner, Chandigarh, Chennai, New Delhi, Dehradun, Mumbai, Guwahati, Hyderabad, Imphal, Itanagar, Jaipur, Jammu, Jodhpur, Kolkata, Lucknow, Patna, Raipur, Indore and Thiruvananthapuram for providing permission and access to sewage treatment plants for sample collection. Dr. Jagadish Deshpande, ICMR-EVRC, Mumbai and Dr. Hemant Purohit, CSIR-NEERI, Nagpur for assistance in sewage sampling from sewage treatment plants of Mumbai. KSS received National Postdoctoral Fellowship (Grant ID: PDF/2016/003317) from Science and Engineering Research Board, Department of Science & Technology, India.
PY - 2023/7
Y1 - 2023/7
N2 - Antimicrobial resistance is raging, but large size of India limits comprehensive exploration. This demands a sample like sewage, which could represent a large population and is often reported to harbor resistant microbes. Here, we did pan-India sewage sampling and studied the antibiotic resistance pattern in the microbial community. We used culture-based antibiotic susceptibility assays and estimated the level of antibiotics present at each site. We found high antibiotic resistance across all cities of India with more diversity of resistance profiles in bigger cities as compared to smaller ones. Bacillus and Pseudomonas were the most common, predominant resistant genera across Indian cities and many sites harbored multi-drug resistant phenotypes. Antibiotic concentrations were below recommended limits at all sites and thus high resistance is not likely caused solely due to antibiotics. Sewage proved to be a good representative for rapidly studying antibiotic resistance in a big country and for similar epidemiological strides.
AB - Antimicrobial resistance is raging, but large size of India limits comprehensive exploration. This demands a sample like sewage, which could represent a large population and is often reported to harbor resistant microbes. Here, we did pan-India sewage sampling and studied the antibiotic resistance pattern in the microbial community. We used culture-based antibiotic susceptibility assays and estimated the level of antibiotics present at each site. We found high antibiotic resistance across all cities of India with more diversity of resistance profiles in bigger cities as compared to smaller ones. Bacillus and Pseudomonas were the most common, predominant resistant genera across Indian cities and many sites harbored multi-drug resistant phenotypes. Antibiotic concentrations were below recommended limits at all sites and thus high resistance is not likely caused solely due to antibiotics. Sewage proved to be a good representative for rapidly studying antibiotic resistance in a big country and for similar epidemiological strides.
KW - Antibiotic resistance
KW - Antibiotic susceptibility testing
KW - MALDI Biotyper-based microbial identification
KW - Pan-India sewage sampling
KW - Sewage treatment plant
UR - http://www.scopus.com/inward/record.url?scp=85164511892&partnerID=8YFLogxK
U2 - 10.22541/au.168180520.09406310/v1
DO - 10.22541/au.168180520.09406310/v1
M3 - Article
AN - SCOPUS:85164511892
VL - 234
JO - Water, Air, and Soil Pollution
JF - Water, Air, and Soil Pollution
SN - 0049-6979
IS - 7
M1 - 467
ER -