TY - JOUR

T1 - Graphitic Carbon Coated Magnetite Nanoparticles for Dual Mode Imaging and Hyperthermia

AU - Tiwari, Ashish

AU - Verma, Navneet C.

AU - Turkkan, Sibel

AU - Debnath, Ayan

AU - Singh, Anup

AU - Dräger, Gerald

AU - Nandi, Chayan K.

AU - Randhawa, Jaspreet K.

N1 - Funding information: The authors are thankful to IIT Mandi for providing experimental facilities to carry out the research work. The authors also thank Dr. R. K. Gupta from the Fortis Memorial Research Institute for assistance in magnetic resonance scanning. A.S. acknowledges funding support from the SERB project (Grant YSS/2014/000092) for MRI imaging. A.T. acknowledges MHRD for the award of senior research fellowship. N.C.V. thanks the Council of Scientific and Industrial Research (CSIR SRF: 9/1058(07)/17-EMR-1) for the award of senior research fellowship.

PY - 2020/1/24

Y1 - 2020/1/24

N2 - Correlating the optical properties to the magnetic properties in superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) will be a boost for future biomedical applications. However, designing such SPIONs without altering its properties is a real challenge. Here, we demonstrate the engineering of the magneto-fluorescent properties simply by tuning the carbon structure in graphitic carbon coated SPIONs. By synthesizing three distinct nanostructures in an easy single step process and studying the in depth structural-functional relationship, we found that the thickness of carbon shell decides the fate of magneto-fluorescent characteristics in SPIONs. Single particle fluorescence data show that the number of emissive photon increases substantially with the increase in the thickness of carbon shell, albeit, the observed relaxivity was enough to get high quality magnetic resonance imaging. The ex vivo magnetic hyperthermia results advanced the use of SPIONs as a single platform for cancer theranostics.

AB - Correlating the optical properties to the magnetic properties in superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) will be a boost for future biomedical applications. However, designing such SPIONs without altering its properties is a real challenge. Here, we demonstrate the engineering of the magneto-fluorescent properties simply by tuning the carbon structure in graphitic carbon coated SPIONs. By synthesizing three distinct nanostructures in an easy single step process and studying the in depth structural-functional relationship, we found that the thickness of carbon shell decides the fate of magneto-fluorescent characteristics in SPIONs. Single particle fluorescence data show that the number of emissive photon increases substantially with the increase in the thickness of carbon shell, albeit, the observed relaxivity was enough to get high quality magnetic resonance imaging. The ex vivo magnetic hyperthermia results advanced the use of SPIONs as a single platform for cancer theranostics.

KW - hyperthermia

KW - magnetic resonance imaging

KW - magneto-fluorescent probe

KW - single particle fluorescence imaging

KW - superparamagnetic iron oxide nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=85078663943&partnerID=8YFLogxK

U2 - 10.1021/acsanm.9b02501

DO - 10.1021/acsanm.9b02501

M3 - Article

AN - SCOPUS:85078663943

VL - 3

SP - 896

EP - 904

JO - ACS Applied Nano Materials

JF - ACS Applied Nano Materials

IS - 1

ER -