TY - JOUR

T1 - Geometric adaption of biodegradable magnesium alloy scaffolds to stabilise biological myocardial grafts. Part I

AU - Bauer, M.

AU - Schilling, T.

AU - Weidling, M.

AU - Hartung, D.

AU - Biskup, Ch

AU - Wriggers, P.

AU - Wacker, F.

AU - Bach, Fr W.

AU - Haverich, A.

AU - Hassel, T.

N1 - Funding information: Acknowledgments The study was conducted within the framework of the collaborative research centre 599 financed by the German Research Foundation (DFG). The authors are very grateful to the DFG for financial support.

PY - 2013/11/22

Y1 - 2013/11/22

N2 - Synthetic patch materials currently in use have major limitations, such as high susceptibility to infections and lack of contractility. Biological grafts are a novel approach to overcome these limitations, but do not always offer sufficient mechanical durability in early stages after implantation. Therefore, a stabilising structure based on resorbable magnesium alloys could support the biological graft until its physiologic remodelling. To prevent early breakage in vivo due to stress of non-determined forming, these scaffolds should be preformed according to the geometry of the targeted myocardial region. Thus, the left ventricular geometry of 28 patients was assessed via standard cardiac magnetic resonance imaging (MRI). The resulting data served as a basis for a finite element simulation (FEM). Calculated stresses and strains of flat and preformed scaffolds were evaluated. Afterwards, the structures were manufactured by abrasive waterjet cutting and preformed according to the MRI data. Finally, the mechanical durability of the preformed and flat structures was compared in an in vitro test rig. The FEM predicted higher durability of the preformed scaffolds, which was proven in the in vitro test. In conclusion, preformed scaffolds provide extended durability and will facilitate more widespread use of regenerative biological grafts for surgical left ventricular reconstruction.

AB - Synthetic patch materials currently in use have major limitations, such as high susceptibility to infections and lack of contractility. Biological grafts are a novel approach to overcome these limitations, but do not always offer sufficient mechanical durability in early stages after implantation. Therefore, a stabilising structure based on resorbable magnesium alloys could support the biological graft until its physiologic remodelling. To prevent early breakage in vivo due to stress of non-determined forming, these scaffolds should be preformed according to the geometry of the targeted myocardial region. Thus, the left ventricular geometry of 28 patients was assessed via standard cardiac magnetic resonance imaging (MRI). The resulting data served as a basis for a finite element simulation (FEM). Calculated stresses and strains of flat and preformed scaffolds were evaluated. Afterwards, the structures were manufactured by abrasive waterjet cutting and preformed according to the MRI data. Finally, the mechanical durability of the preformed and flat structures was compared in an in vitro test rig. The FEM predicted higher durability of the preformed scaffolds, which was proven in the in vitro test. In conclusion, preformed scaffolds provide extended durability and will facilitate more widespread use of regenerative biological grafts for surgical left ventricular reconstruction.

UR - http://www.scopus.com/inward/record.url?scp=84896509653&partnerID=8YFLogxK

U2 - 10.1007/s10856-013-5100-5

DO - 10.1007/s10856-013-5100-5

M3 - Article

C2 - 24264726

AN - SCOPUS:84896509653

VL - 25

SP - 909

EP - 916

JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

SN - 0957-4530

IS - 3

ER -