Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 182-187 |
| Seitenumfang | 6 |
| Fachzeitschrift | Organic and Biomolecular Chemistry |
| Jahrgang | 19 |
| Ausgabenummer | 1 |
| Frühes Online-Datum | 23 Okt. 2020 |
| Publikationsstatus | Veröffentlicht - 7 Jan. 2021 |
Abstract
Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified. This journal is
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Chemie (insg.)
- Physikalische und Theoretische Chemie
- Chemie (insg.)
- Organische Chemie
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in: Organic and Biomolecular Chemistry, Jahrgang 19, Nr. 1, 07.01.2021, S. 182-187.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari
AU - Marshall, James W.
AU - de Mattos-Shipley, Kate M. J.
AU - Ghannam, Iman A. Y.
AU - Munawar, Asifa
AU - Killen, Jonathan C.
AU - Lazarus, Colin M.
AU - Cox, Russell J.
AU - Willis, Christine L.
AU - Simpson, Thomas J.
N1 - Funding Information: We thank MRC (MR/N029909/1) (KMJdeM-S), EPSRC (EP/ E000177/1) (JCK), the Ministry of Higher Education (MOHE) – Egypt (IAYG), and the Higher Education Commission of Pakistan (AM) for financial support. JWM thanks BBSRC and Mr Mark Evans for PhD scholarships. X-ray crystallography was carried out by Dr Mairi Haddow, School of Chemistry, University of Bristol.
PY - 2021/1/7
Y1 - 2021/1/7
N2 - Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified. This journal is
AB - Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified. This journal is
UR - http://www.scopus.com/inward/record.url?scp=85099180447&partnerID=8YFLogxK
U2 - 10.1039/d0ob02031a
DO - 10.1039/d0ob02031a
M3 - Article
VL - 19
SP - 182
EP - 187
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 1
ER -