Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 6 |
| Fachzeitschrift | BMC cell biology |
| Jahrgang | 18 |
| Ausgabenummer | Suppl 1 |
| Publikationsstatus | Veröffentlicht - 17 Jan. 2017 |
Abstract
The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50). Epithelial Cx50 has critical roles in cell proliferation and differentiation, likely involving growth factor-dependent signaling pathways. Both Cx46 and Cx50 are crucial for lens transparency; mutations in their genes have been linked to congenital and age-related cataracts. Congenital cataract-associated connexin mutants can affect protein trafficking, stability and/or function, and the functional effects may differ between gap junction channels and hemichannels. Dominantly inherited cataracts may result from effects of the connexin mutant on its wild type isotype, the other co-expressed wild type connexin and/or its interaction with other cellular components.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Zellbiologie
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in: BMC cell biology, Jahrgang 18, Nr. Suppl 1, 6, 17.01.2017.
Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review
}
TY - JOUR
T1 - Focus on lens connexins
AU - Berthoud, Viviana M
AU - Ngezahayo, Anaclet
N1 - Funding information: This article was funded by US National Institutes of Health Grant RO1EY08368 and The DFG Sonderforschungsbereich / Transregio 37.
PY - 2017/1/17
Y1 - 2017/1/17
N2 - The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50). Epithelial Cx50 has critical roles in cell proliferation and differentiation, likely involving growth factor-dependent signaling pathways. Both Cx46 and Cx50 are crucial for lens transparency; mutations in their genes have been linked to congenital and age-related cataracts. Congenital cataract-associated connexin mutants can affect protein trafficking, stability and/or function, and the functional effects may differ between gap junction channels and hemichannels. Dominantly inherited cataracts may result from effects of the connexin mutant on its wild type isotype, the other co-expressed wild type connexin and/or its interaction with other cellular components.
AB - The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50). Epithelial Cx50 has critical roles in cell proliferation and differentiation, likely involving growth factor-dependent signaling pathways. Both Cx46 and Cx50 are crucial for lens transparency; mutations in their genes have been linked to congenital and age-related cataracts. Congenital cataract-associated connexin mutants can affect protein trafficking, stability and/or function, and the functional effects may differ between gap junction channels and hemichannels. Dominantly inherited cataracts may result from effects of the connexin mutant on its wild type isotype, the other co-expressed wild type connexin and/or its interaction with other cellular components.
KW - Animals
KW - Cataract/genetics
KW - Connexins/chemistry
KW - Humans
KW - Intercellular Signaling Peptides and Proteins/metabolism
KW - Lens, Crystalline/metabolism
KW - Mutation/genetics
KW - Signal Transduction
UR - http://www.scopus.com/inward/record.url?scp=85009966934&partnerID=8YFLogxK
U2 - 10.1186/s12860-016-0116-6
DO - 10.1186/s12860-016-0116-6
M3 - Review article
C2 - 28124626
VL - 18
JO - BMC cell biology
JF - BMC cell biology
SN - 1471-2121
IS - Suppl 1
M1 - 6
ER -