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First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: Evidence for the mechanism of chain length determination

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autorschaft

  • T. P. Nicholson
  • C. Winfield
  • J. Westcott
  • J. Crosby
  • R. J. Cox

Externe Organisationen

  • University of Bristol
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    • Citation Indexes: 34
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Details

OriginalspracheEnglisch
Seiten (von - bis)686-687
Seitenumfang2
FachzeitschriftChemical communications
Jahrgang3
Ausgabenummer6
PublikationsstatusVeröffentlicht - 1 Jan. 2003
Extern publiziertJa

Abstract

The minimal actinorhodin polyketide synthase bearing two point mutations (KSβ Q161A, ACP C17S) was chemically modified to carry novel C4 to C8 starter units on the ACP: on incubation with an excess of malonyl CoA new 16-carbon polyketides are made, supporting a measuring mechanism.

ASJC Scopus Sachgebiete

Zitieren

First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: Evidence for the mechanism of chain length determination. / Nicholson, T. P.; Winfield, C.; Westcott, J. et al.
in: Chemical communications, Jahrgang 3, Nr. 6, 01.01.2003, S. 686-687.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Download
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AU - Cox, R. J.

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