Details
| Originalsprache | Englisch |
|---|---|
| Titel des Sammelwerks | European Conference on Biomedical Optics, ECBO 2009 |
| Herausgeber (Verlag) | OSA - The Optical Society |
| ISBN (Print) | 9780819476432 |
| Publikationsstatus | Veröffentlicht - 17 Juli 2009 |
| Extern publiziert | Ja |
| Veranstaltung | European Conference on Biomedical Optics, ECBO 2009 - Munich, Deutschland Dauer: 14 Juni 2009 → 18 Juni 2009 |
Publikationsreihe
| Name | Optics InfoBase Conference Papers |
|---|---|
| ISSN (elektronisch) | 2162-2701 |
Abstract
ASJC Scopus Sachgebiete
- Physik und Astronomie (insg.)
- Instrumentierung
- Physik und Astronomie (insg.)
- Atom- und Molekularphysik sowie Optik
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European Conference on Biomedical Optics, ECBO 2009. OSA - The Optical Society, 2009. (Optics InfoBase Conference Papers).
Publikation: Beitrag in Buch/Bericht/Sammelwerk/Konferenzband › Aufsatz in Konferenzband › Forschung › Peer-Review
}
TY - GEN
T1 - Femtosecond laser microstructuring of titanium surfaces for middle ear ossicular replacement prosthesis-results of preliminary studies
AU - Biedron, S.
AU - Ilgner, J. F.R.
AU - Fadeeva, E.
AU - Chichkov, B.
AU - Prescher, A.
AU - Bovi, M.
AU - Westhofen, M.
PY - 2009/7/17
Y1 - 2009/7/17
N2 - The objective of this study was to optimize titanium surfaces by means of Ti:Sapphire femtosecond laser to improve the attachment of human cartilage cells on titanium prosthesis in middle ear surgery. The application of microstructures on titanium samples was evaluated and the influence of these microstructures on human auricular chondrocytes was studied in-vitro. After establishing the ear chondrocyte cell culture, cells were seeded on titanium platelets with selected microstructure patterns. Whereas the phenotype of cells seeded on unstructured titanium was similar to cells grown on standard tissue culture surfaces, the morphology of chondrocytes grown on structured titanium samples was influenced by the pattern. For future titanium middle ear prosthesis structural optimizations will be developed to promote chondrocyte growth and adhesion while impeding fibrocyte proliferation to avoid scarring on implant interfaces.
AB - The objective of this study was to optimize titanium surfaces by means of Ti:Sapphire femtosecond laser to improve the attachment of human cartilage cells on titanium prosthesis in middle ear surgery. The application of microstructures on titanium samples was evaluated and the influence of these microstructures on human auricular chondrocytes was studied in-vitro. After establishing the ear chondrocyte cell culture, cells were seeded on titanium platelets with selected microstructure patterns. Whereas the phenotype of cells seeded on unstructured titanium was similar to cells grown on standard tissue culture surfaces, the morphology of chondrocytes grown on structured titanium samples was influenced by the pattern. For future titanium middle ear prosthesis structural optimizations will be developed to promote chondrocyte growth and adhesion while impeding fibrocyte proliferation to avoid scarring on implant interfaces.
KW - Biomaterials
KW - Cell culture
KW - Chondrocyte
KW - Contact guidance
KW - Ear cartilage
KW - Femtosecond laser
KW - Microstructures
KW - Titanium
UR - http://www.scopus.com/inward/record.url?scp=84898013523&partnerID=8YFLogxK
U2 - DOI:10.1117/12.831883
DO - DOI:10.1117/12.831883
M3 - Conference contribution
AN - SCOPUS:84898013523
SN - 9780819476432
T3 - Optics InfoBase Conference Papers
BT - European Conference on Biomedical Optics, ECBO 2009
PB - OSA - The Optical Society
T2 - European Conference on Biomedical Optics, ECBO 2009
Y2 - 14 June 2009 through 18 June 2009
ER -