Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1114-1121 |
| Seitenumfang | 8 |
| Fachzeitschrift | Analytical chemistry |
| Jahrgang | 90 |
| Ausgabenummer | 2 |
| Publikationsstatus | Veröffentlicht - 22 Dez. 2017 |
Abstract
Ion mobility spectrometry is a powerful and low-cost technique for the identification of chemical warfare agents, toxic chemicals, or explosives in air. Drift tube ion mobility spectrometers (DT-IMS) separate ions by the absolute value of their low field ion mobility, while field asymmetric ion mobility spectrometers (FAIMS) separate them by the change of their ion mobility at high fields. However, using one of these devices alone, some common and harmless substances show the same response as the hazardous target substances. In order to increase the selectivity, orthogonal data are required. Thus, in this work, we present for the first time an ambient pressure ion mobility spectrometer which is able to separate ions both by their differential and low field mobility, providing additional information for selectivity enhancement. This novel field asymmetric time of flight ion mobility spectrometer (FAT-IMS) allows high repetition rates and reaches limits of detection in the low ppb range common for DT-IMS. The device consists of a compact 44 mm drift tube with a tritium ionization source and a resolving power of 70. An increased separation of four substances with similar low field ion mobility is shown: phosgene (K0 = 2.33 cm2/(V s)), 1,1,2-trichlorethane (K0 = 2.31 cm2/(V s)), chlorine (K0 = 2.24 cm2/(V s)), and nitrogen dioxide (K0 = 2.25 cm2/(V s)). Furthermore, the behavior and limits of detection for acetonitrile, dimethyl methylphosphonate, diisopropyl methyl phosphonate in positive polarity and carbon dioxide, sulfur dioxide, hydrochloric acid, cyanogen chloride, and hydrogen cyanide in negative polarity are investigated.
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in: Analytical chemistry, Jahrgang 90, Nr. 2, 22.12.2017, S. 1114-1121.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Fast Orthogonal Separation by Superposition of Time of Flight and Field Asymmetric Ion Mobility Spectrometry
AU - Bohnhorst, Alexander
AU - Kirk, Ansgar T.
AU - Berger, Marc
AU - Zimmermann, Stefan
N1 - Funding information: We would like to thank Airsense Analytics for providing the laboratory for the measurements. This work has been supported by the German Federal Ministry of Economics and Technology (BMWi), under the Grant KF3238301NT3 upon decision of the German Bundestag.
PY - 2017/12/22
Y1 - 2017/12/22
N2 - Ion mobility spectrometry is a powerful and low-cost technique for the identification of chemical warfare agents, toxic chemicals, or explosives in air. Drift tube ion mobility spectrometers (DT-IMS) separate ions by the absolute value of their low field ion mobility, while field asymmetric ion mobility spectrometers (FAIMS) separate them by the change of their ion mobility at high fields. However, using one of these devices alone, some common and harmless substances show the same response as the hazardous target substances. In order to increase the selectivity, orthogonal data are required. Thus, in this work, we present for the first time an ambient pressure ion mobility spectrometer which is able to separate ions both by their differential and low field mobility, providing additional information for selectivity enhancement. This novel field asymmetric time of flight ion mobility spectrometer (FAT-IMS) allows high repetition rates and reaches limits of detection in the low ppb range common for DT-IMS. The device consists of a compact 44 mm drift tube with a tritium ionization source and a resolving power of 70. An increased separation of four substances with similar low field ion mobility is shown: phosgene (K0 = 2.33 cm2/(V s)), 1,1,2-trichlorethane (K0 = 2.31 cm2/(V s)), chlorine (K0 = 2.24 cm2/(V s)), and nitrogen dioxide (K0 = 2.25 cm2/(V s)). Furthermore, the behavior and limits of detection for acetonitrile, dimethyl methylphosphonate, diisopropyl methyl phosphonate in positive polarity and carbon dioxide, sulfur dioxide, hydrochloric acid, cyanogen chloride, and hydrogen cyanide in negative polarity are investigated.
AB - Ion mobility spectrometry is a powerful and low-cost technique for the identification of chemical warfare agents, toxic chemicals, or explosives in air. Drift tube ion mobility spectrometers (DT-IMS) separate ions by the absolute value of their low field ion mobility, while field asymmetric ion mobility spectrometers (FAIMS) separate them by the change of their ion mobility at high fields. However, using one of these devices alone, some common and harmless substances show the same response as the hazardous target substances. In order to increase the selectivity, orthogonal data are required. Thus, in this work, we present for the first time an ambient pressure ion mobility spectrometer which is able to separate ions both by their differential and low field mobility, providing additional information for selectivity enhancement. This novel field asymmetric time of flight ion mobility spectrometer (FAT-IMS) allows high repetition rates and reaches limits of detection in the low ppb range common for DT-IMS. The device consists of a compact 44 mm drift tube with a tritium ionization source and a resolving power of 70. An increased separation of four substances with similar low field ion mobility is shown: phosgene (K0 = 2.33 cm2/(V s)), 1,1,2-trichlorethane (K0 = 2.31 cm2/(V s)), chlorine (K0 = 2.24 cm2/(V s)), and nitrogen dioxide (K0 = 2.25 cm2/(V s)). Furthermore, the behavior and limits of detection for acetonitrile, dimethyl methylphosphonate, diisopropyl methyl phosphonate in positive polarity and carbon dioxide, sulfur dioxide, hydrochloric acid, cyanogen chloride, and hydrogen cyanide in negative polarity are investigated.
UR - http://www.scopus.com/inward/record.url?scp=85040672141&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.7b03200
DO - 10.1021/acs.analchem.7b03200
M3 - Article
C2 - 29271643
AN - SCOPUS:85040672141
VL - 90
SP - 1114
EP - 1121
JO - Analytical chemistry
JF - Analytical chemistry
SN - 0003-2700
IS - 2
ER -