Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 473-479 |
| Seitenumfang | 7 |
| Fachzeitschrift | Journal of Heterocyclic Chemistry |
| Jahrgang | 54 |
| Ausgabenummer | 1 |
| Publikationsstatus | Veröffentlicht - Jan. 2017 |
Abstract
Arylhydrazones are prepared and reacted with pyrazolylmethylene malononitrile derivatives yielding 2,5-dihydropyridazines substituted at C-5 by pyrazole derivatives. Utilizing azaenamine containing a cyano group at the ortho position enabled the formation of the condensed pyridazino[1,6-a]quinazoline derivatives. A subsequent acetylation of the synthesized pyridazines led to the formation of pyrimido[4,5-c]pyridazine compounds which can be considered as 4-deazatoxoflavin derivatives. All the new compounds were full-characterized by the different spectral tools and the unambiguous structural elucidation of 2,5-dihydropyridazines was done using 2D-HMBC spectroscopy.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Organische Chemie
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in: Journal of Heterocyclic Chemistry, Jahrgang 54, Nr. 1, 01.2017, S. 473-479.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Facile Synthesis of 3-Amino-2,5-dihydropyridazines and 4-Deazatoxoflavin Analogues via [3 + 3] Atom Combination
T2 - Approaches to Pyridazine Incorporating Pyrazole Moiety
AU - Abdelmoniem, Amr M.
AU - Ghozlan, Said A.S.
AU - Butenschön, Holger
AU - Abdelhamid, Ismail A.
N1 - Publisher Copyright: © 2016 Wiley Periodicals, Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2017/1
Y1 - 2017/1
N2 - Arylhydrazones are prepared and reacted with pyrazolylmethylene malononitrile derivatives yielding 2,5-dihydropyridazines substituted at C-5 by pyrazole derivatives. Utilizing azaenamine containing a cyano group at the ortho position enabled the formation of the condensed pyridazino[1,6-a]quinazoline derivatives. A subsequent acetylation of the synthesized pyridazines led to the formation of pyrimido[4,5-c]pyridazine compounds which can be considered as 4-deazatoxoflavin derivatives. All the new compounds were full-characterized by the different spectral tools and the unambiguous structural elucidation of 2,5-dihydropyridazines was done using 2D-HMBC spectroscopy.
AB - Arylhydrazones are prepared and reacted with pyrazolylmethylene malononitrile derivatives yielding 2,5-dihydropyridazines substituted at C-5 by pyrazole derivatives. Utilizing azaenamine containing a cyano group at the ortho position enabled the formation of the condensed pyridazino[1,6-a]quinazoline derivatives. A subsequent acetylation of the synthesized pyridazines led to the formation of pyrimido[4,5-c]pyridazine compounds which can be considered as 4-deazatoxoflavin derivatives. All the new compounds were full-characterized by the different spectral tools and the unambiguous structural elucidation of 2,5-dihydropyridazines was done using 2D-HMBC spectroscopy.
UR - http://www.scopus.com/inward/record.url?scp=84961221385&partnerID=8YFLogxK
U2 - 10.1002/jhet.2606
DO - 10.1002/jhet.2606
M3 - Article
AN - SCOPUS:84961221385
VL - 54
SP - 473
EP - 479
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
SN - 0022-152X
IS - 1
ER -