TY - JOUR

T1 - Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing

AU - Torres-Mapa, Maria Leilani

AU - Singh, Manmeet

AU - Simon, Olga

AU - Mapa, Jose Louise

AU - Machida, Manan

AU - Günther, Axel

AU - Roth, Bernhard

AU - Heinemann, Dag

AU - Terakawa, Mitsuhiro

AU - Heisterkamp, Alexander

N1 - Funding information: This work is supported by the Federal Ministry of Education and Research, Germany (13N14085) and the German Research Foundation, Germany Clusters of Excellence: REBIRTH (EXC 62) and Hearing4all (EXC 2177). Acknowledgments: The publication of this article was funded by the Open Access fund of Leibniz Universität Hannover. We would like to acknowledge Kotaro Obata for early support on PDMS material and Manuel Fernandez for 3D-printing of the molds.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

AB - Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.

KW - 3D printing

KW - Fluorescence

KW - Hydrogels

KW - Microfluidics

KW - Waveguide

UR - http://www.scopus.com/inward/record.url?scp=85073097837&partnerID=8YFLogxK

U2 - 10.3390/s19194333

DO - 10.3390/s19194333

M3 - Article

C2 - 31597248

AN - SCOPUS:85073097837

VL - 19

JO - Sensors (Switzerland)

JF - Sensors (Switzerland)

SN - 1424-8220

IS - 19

M1 - 4333

ER -