Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 95-98 |
| Seitenumfang | 4 |
| Fachzeitschrift | The FEBS journal |
| Jahrgang | 288 |
| Ausgabenummer | 1 |
| Frühes Online-Datum | 17 Juni 2020 |
| Publikationsstatus | Veröffentlicht - 4 Jan. 2021 |
Abstract
Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In the human pathogen Mtb, this crucial cellular task is performed by several ATPase associated with diverse cellular activities proteases including ClpC1P. Ziemski et al. performed a bacterial adenylate cyclase two-hybrid screen to identify ClpC1 substrates and showed the Type II TA systems represent a major group of ClpC1-interacting proteins. Comment on: https://doi.org/10.1111/febs.15335.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularbiologie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Zellbiologie
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in: The FEBS journal, Jahrgang 288, Nr. 1, 04.01.2021, S. 95-98.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Exploring a potential Achilles heel of Mycobacterium tuberculosis
T2 - defining the ClpC1 interactome
AU - Dougan, David A.
AU - Alver, Regina
AU - Turgay, Kürşad
N1 - Funding information: The work in the Lab of KT is supported by the Max Planck Society and the Deutsche Forschungsgemeinschaft.
PY - 2021/1/4
Y1 - 2021/1/4
N2 - Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In the human pathogen Mtb, this crucial cellular task is performed by several ATPase associated with diverse cellular activities proteases including ClpC1P. Ziemski et al. performed a bacterial adenylate cyclase two-hybrid screen to identify ClpC1 substrates and showed the Type II TA systems represent a major group of ClpC1-interacting proteins. Comment on: https://doi.org/10.1111/febs.15335.
AB - Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In the human pathogen Mtb, this crucial cellular task is performed by several ATPase associated with diverse cellular activities proteases including ClpC1P. Ziemski et al. performed a bacterial adenylate cyclase two-hybrid screen to identify ClpC1 substrates and showed the Type II TA systems represent a major group of ClpC1-interacting proteins. Comment on: https://doi.org/10.1111/febs.15335.
KW - AAA+ protease complex
KW - adaptor proteins
KW - antibiotic target
KW - ClpCP
KW - Mycobacterium tuberculosis
KW - N-degrons
KW - proteolysis
UR - http://www.scopus.com/inward/record.url?scp=85098605189&partnerID=8YFLogxK
U2 - 10.1111/febs.15430
DO - 10.1111/febs.15430
M3 - Article
C2 - 32571006
VL - 288
SP - 95
EP - 98
JO - The FEBS journal
JF - The FEBS journal
SN - 1742-464X
IS - 1
ER -