TY - JOUR

T1 - Engineering of biodegradable magnesium alloy scaffolds to stabilize biological myocardial grafts

AU - Schilling, T.

AU - Bauer, Michael

AU - Biskup, Christian

AU - Haverich, A.

AU - Hassel, Thomas

N1 - Funding information: Acknowledgments: The results presented here were acquired within the framework of the collaborative research center 599 financed by the German Research Foundation (DFG). The authors thank the DFG for financial support. The authors declare that there are no conflicts of interest. There was no involvement of the sponsor in the research or the preparation of this article.

PY - 2017/5/19

Y1 - 2017/5/19

N2 - Regenerative bioprostheses are being investigated for replacement of dysfunctional myocardium worldwide. The aim of this study was to develop a degradable magnesium structure to mechanically support the delicate biological grafts during the early remodeling phase. Sheets of magnesium alloys (LA33, LA63 and AX30) were manufactured into scaffolds by abrasive water jet cutting. Thereafter, their surface properties, corrosion kinetics, and breakage behaviors were investigated. The magnesium alloy LA63 sheets proved superior to the other alloys in terms of load cycles (lc) until break of the specimens (LA63: >10 Mio lc; AX30: 676,044±220,016 lc; LA33: 423,558±210,063 lc; p<0.01). Coating with MgF led to better protection than coating with MagPass. Less complex, yet sufficiently flexible scaffolds were less prone to early breakage. A slow traverse rate during water jet cutting resulted in the lowest burr, but in a widening of the kerf width from 615±11 μm at 500 mm/min to 708±33 μm at 10 mm/min (p<0.01). The findings on alloy composition, coating, structural geometry and manufacturing parameters constitute a basis for clinically applicable magnesium scaffolds. The use of stabilized, regenerative myocardium prostheses could save the patients from severe morbidity and eventually death.

AB - Regenerative bioprostheses are being investigated for replacement of dysfunctional myocardium worldwide. The aim of this study was to develop a degradable magnesium structure to mechanically support the delicate biological grafts during the early remodeling phase. Sheets of magnesium alloys (LA33, LA63 and AX30) were manufactured into scaffolds by abrasive water jet cutting. Thereafter, their surface properties, corrosion kinetics, and breakage behaviors were investigated. The magnesium alloy LA63 sheets proved superior to the other alloys in terms of load cycles (lc) until break of the specimens (LA63: >10 Mio lc; AX30: 676,044±220,016 lc; LA33: 423,558±210,063 lc; p<0.01). Coating with MgF led to better protection than coating with MagPass. Less complex, yet sufficiently flexible scaffolds were less prone to early breakage. A slow traverse rate during water jet cutting resulted in the lowest burr, but in a widening of the kerf width from 615±11 μm at 500 mm/min to 708±33 μm at 10 mm/min (p<0.01). The findings on alloy composition, coating, structural geometry and manufacturing parameters constitute a basis for clinically applicable magnesium scaffolds. The use of stabilized, regenerative myocardium prostheses could save the patients from severe morbidity and eventually death.

KW - biological grafts

KW - cardiac surgery

KW - coating

KW - magnesium alloys

KW - stabilizing scaffolds

KW - water jet abrasive cutting

UR - http://www.scopus.com/inward/record.url?scp=85031036410&partnerID=8YFLogxK

U2 - 10.1515/bmt-2016-0205

DO - 10.1515/bmt-2016-0205

M3 - Article

VL - 62

SP - 493

EP - 504

JO - Biomedizinische Technik

JF - Biomedizinische Technik

SN - 0013-5585

IS - 5

ER -