Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 3271-3274 |
| Seitenumfang | 4 |
| Fachzeitschrift | Angewandte Chemie |
| Jahrgang | 50 |
| Ausgabenummer | 14 |
| Publikationsstatus | Veröffentlicht - 28 März 2011 |
| Extern publiziert | Ja |
Abstract
New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
- Allgemeine Chemie
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in: Angewandte Chemie , Jahrgang 50, Nr. 14, 28.03.2011, S. 3271-3274.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390
AU - Murphy, Annabel C.
AU - Fukuda, Daisuke
AU - Song, Zhongshu
AU - Hothersall, Joanne
AU - Cox, Russell J.
AU - Willis, Christine L.
AU - Thomas, Christopher M.
AU - Simpson, Thomas J.
PY - 2011/3/28
Y1 - 2011/3/28
N2 - New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.
AB - New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.
KW - antibiotics
KW - biosynthesis
KW - methicillin resistance
KW - mupirocin
KW - thiomarinol
UR - http://www.scopus.com/inward/record.url?scp=79952999917&partnerID=8YFLogxK
U2 - 10.1002/anie.201007029
DO - 10.1002/anie.201007029
M3 - Article
C2 - 21381163
AN - SCOPUS:79952999917
VL - 50
SP - 3271
EP - 3274
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 14
ER -