Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 9914-9917 |
| Seitenumfang | 4 |
| Fachzeitschrift | Angewandte Chemie - International Edition |
| Jahrgang | 51 |
| Ausgabenummer | 39 |
| Frühes Online-Datum | 31 Aug. 2012 |
| Publikationsstatus | Veröffentlicht - 24 Sept. 2012 |
| Extern publiziert | Ja |
Abstract
Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
- Allgemeine Chemie
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in: Angewandte Chemie - International Edition, Jahrgang 51, Nr. 39, 24.09.2012, S. 9914-9917.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase
AU - Könst, Paul
AU - Merkens, Hedda
AU - Kara, Selin
AU - Kochius, Svenja
AU - Vogel, Andreas
AU - Zuhse, Ralf
AU - Holtmann, Dirk
AU - Arends, Isabel W.C.E.
AU - Hollmann, Frank
PY - 2012/9/24
Y1 - 2012/9/24
N2 - Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.
AB - Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity.
KW - alcohol dehydrogenases
KW - alcohol oxidation
KW - aldehyde oxidation
KW - dynamic kinetic resolution
KW - profens
UR - http://www.scopus.com/inward/record.url?scp=84866509198&partnerID=8YFLogxK
U2 - 10.1002/anie.201203219
DO - 10.1002/anie.201203219
M3 - Article
C2 - 22936647
AN - SCOPUS:84866509198
VL - 51
SP - 9914
EP - 9917
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 39
ER -