TY - JOUR

T1 - Employers With Metabolic Syndrome and Increased Depression/Anxiety Severity Profit Most From Structured Exercise Intervention for Work Ability and Quality of Life.

AU - Haufe, Sven

AU - Kahl, Kai G.

AU - Kerling, Arno

AU - Protte, Gudrun

AU - Bayerle, Pauline

AU - Stenner, Hedwig T.

AU - Rolff, Simone

AU - Sundermeier, Thorben

AU - Eigendorf, Julian

AU - Kück, Momme

AU - Hanke, Alexander A.

AU - Keller-Varady, Katriona

AU - Ensslen, Ralf

AU - Nachbar, Lars

AU - Lauenstein, Dirk

AU - Böthig, Dietmar

AU - Terkamp, Christoph

AU - Stiesch, Meike

AU - Hilfiker-Kleiner, Denise

AU - Haverich, Axel

AU - Tegtbur, Uwe

PY - 2020/6/18

Y1 - 2020/6/18

N2 - Background: Major depressive disorder and anxiety disorders are associated with less productivity, earlier retirement, and more sick-days at the workplace. These associations also exist for patients with metabolic syndrome. For both, exercise is a generally recommended part of multimodal treatments. However, for individuals with metabolic syndrome, in which depression and anxiety is more prevalent and severe, evidence for the efficacy of exercise interventions is limited. Methods: Company employees with diagnosed metabolic syndrome (n=314, age: 48 ± 8 yrs) were randomized to a 6-month exercise intervention (150 min per week) or wait-list control. Participants received individual recommendations for exercise activities by personal meetings, telephone, or via a smartphone app. Physical activities were supervised and adapted using activity monitor data transferred to a central database. Work ability (work ability index), depression severity and anxiety severity [hospital anxiety and depression scale (HADS)], and health-related quality of live [short form 36 (SF-36)] were assessed. Results: We included 314 subjects from which 287 finished the intervention. Total work ability, depression- and anxiety severity, and the mental component score of the SF-36 improved after 6 months exercise compared to controls. After baseline stratification for normal (HADS scores 0–7) and increased depression- and anxiety scores (HADS scores 8–21) individuals with increased severity scores had similar age, body composition, blood lipids, and cardiorespiratory fitness compared to those with normal scores, but lower total work ability and component sum scores of health-related quality of life. After 6 months total work ability increased in the exercise group compared to controls with the magnitude of the observed increase being significantly greater for subjects with increased depression- and anxiety severity at baseline compared to those with normal severity scores. Conclusions: A 6-month exercise intervention for company employees with metabolic syndrome showed strongest effects on self-perceived work ability in individuals with mild to severe depression- and anxiety severity. This suggests exercise programs offered to workers with metabolic syndrome not only reduces individual disease risk but may also reduce healthcare and employers costs arising from metabolic syndrome and mental disease conditions. Clinical Trial Registration: ClinicalTrials.gov, identifier NCT03293264.

AB - Background: Major depressive disorder and anxiety disorders are associated with less productivity, earlier retirement, and more sick-days at the workplace. These associations also exist for patients with metabolic syndrome. For both, exercise is a generally recommended part of multimodal treatments. However, for individuals with metabolic syndrome, in which depression and anxiety is more prevalent and severe, evidence for the efficacy of exercise interventions is limited. Methods: Company employees with diagnosed metabolic syndrome (n=314, age: 48 ± 8 yrs) were randomized to a 6-month exercise intervention (150 min per week) or wait-list control. Participants received individual recommendations for exercise activities by personal meetings, telephone, or via a smartphone app. Physical activities were supervised and adapted using activity monitor data transferred to a central database. Work ability (work ability index), depression severity and anxiety severity [hospital anxiety and depression scale (HADS)], and health-related quality of live [short form 36 (SF-36)] were assessed. Results: We included 314 subjects from which 287 finished the intervention. Total work ability, depression- and anxiety severity, and the mental component score of the SF-36 improved after 6 months exercise compared to controls. After baseline stratification for normal (HADS scores 0–7) and increased depression- and anxiety scores (HADS scores 8–21) individuals with increased severity scores had similar age, body composition, blood lipids, and cardiorespiratory fitness compared to those with normal scores, but lower total work ability and component sum scores of health-related quality of life. After 6 months total work ability increased in the exercise group compared to controls with the magnitude of the observed increase being significantly greater for subjects with increased depression- and anxiety severity at baseline compared to those with normal severity scores. Conclusions: A 6-month exercise intervention for company employees with metabolic syndrome showed strongest effects on self-perceived work ability in individuals with mild to severe depression- and anxiety severity. This suggests exercise programs offered to workers with metabolic syndrome not only reduces individual disease risk but may also reduce healthcare and employers costs arising from metabolic syndrome and mental disease conditions. Clinical Trial Registration: ClinicalTrials.gov, identifier NCT03293264.

KW - activity devices

KW - mental health

KW - physical activity

KW - productivity

KW - telemonitoring

UR - http://www.scopus.com/inward/record.url?scp=85087310704&partnerID=8YFLogxK

U2 - 10.3389/fpsyt.2020.00562

DO - 10.3389/fpsyt.2020.00562

M3 - Article

AN - SCOPUS:85087310704

VL - 11

JO - Frontiers in psychiatry

JF - Frontiers in psychiatry

SN - 1664-0640

M1 - 562

ER -