Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1025-1032 |
| Seitenumfang | 8 |
| Fachzeitschrift | Fibers and polymers |
| Jahrgang | 17 |
| Ausgabenummer | 7 |
| Publikationsstatus | Veröffentlicht - 1 Juli 2016 |
Abstract
Tissue engineering is an interdisciplinary field which combines the basic principles of life sciences and engineering. One promising idea is the combination of scaffolds and living cells in order to produce new functional tissue. The scaffolds play the role of a microenvironment that guides the cells towards tissue formation and regeneration. One of the most frequently used techniques to produce scaffolds is electrospinning. Tissue engineered constructs have to exhibit physiological and mechanical properties comparable to the native tissue they are intended to replace. To create polymeric fibers with controlled orientation, a cylindrical collector that rotates at a certain speed could be used, creating fibers that run longitudinally. The process of gap-spinning enables the production of specifically aligned fibers. Aim of this study was to develop a novel setup capable of producing multilayered structures with controlled fiber angle. The structural, morphological and mechanical characteristics of the fibers were accessed using scanning electron microscopy and uniaxial tensile tests. Longer pre-stretching led to thinner (in the sub-micron scale), more brittle and less elastic fibers. In a nutshell, the results indicated that fiber mats of desired orientation, fiber diameter and mechanical properties could be produced by controlled gap-spinning with a translational collector.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Allgemeine Chemie
- Chemische Verfahrenstechnik (insg.)
- Allgemeine chemische Verfahrenstechnik
- Werkstoffwissenschaften (insg.)
- Polymere und Kunststoffe
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in: Fibers and polymers, Jahrgang 17, Nr. 7, 01.07.2016, S. 1025-1032.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Electrospinning and mechanical properties of polymeric fibers using a novel gap-spinning collector
AU - Zernetsch, Holger
AU - Repanas, Alexandros
AU - Rittinghaus, Tim
AU - Mueller, Marc
AU - Alfred, Irene
AU - Glasmacher, Birgit
N1 - This research was granted (DFG EXC 62/1) by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) and by the Niedersächsisches Ministerium für Wissenschaft und Kultur (MWK) in the joint project SynFoBiA – “Novel synthesis and formulation methods for poorly soluble drugs and sensitive biopharmaceuticals”.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Tissue engineering is an interdisciplinary field which combines the basic principles of life sciences and engineering. One promising idea is the combination of scaffolds and living cells in order to produce new functional tissue. The scaffolds play the role of a microenvironment that guides the cells towards tissue formation and regeneration. One of the most frequently used techniques to produce scaffolds is electrospinning. Tissue engineered constructs have to exhibit physiological and mechanical properties comparable to the native tissue they are intended to replace. To create polymeric fibers with controlled orientation, a cylindrical collector that rotates at a certain speed could be used, creating fibers that run longitudinally. The process of gap-spinning enables the production of specifically aligned fibers. Aim of this study was to develop a novel setup capable of producing multilayered structures with controlled fiber angle. The structural, morphological and mechanical characteristics of the fibers were accessed using scanning electron microscopy and uniaxial tensile tests. Longer pre-stretching led to thinner (in the sub-micron scale), more brittle and less elastic fibers. In a nutshell, the results indicated that fiber mats of desired orientation, fiber diameter and mechanical properties could be produced by controlled gap-spinning with a translational collector.
AB - Tissue engineering is an interdisciplinary field which combines the basic principles of life sciences and engineering. One promising idea is the combination of scaffolds and living cells in order to produce new functional tissue. The scaffolds play the role of a microenvironment that guides the cells towards tissue formation and regeneration. One of the most frequently used techniques to produce scaffolds is electrospinning. Tissue engineered constructs have to exhibit physiological and mechanical properties comparable to the native tissue they are intended to replace. To create polymeric fibers with controlled orientation, a cylindrical collector that rotates at a certain speed could be used, creating fibers that run longitudinally. The process of gap-spinning enables the production of specifically aligned fibers. Aim of this study was to develop a novel setup capable of producing multilayered structures with controlled fiber angle. The structural, morphological and mechanical characteristics of the fibers were accessed using scanning electron microscopy and uniaxial tensile tests. Longer pre-stretching led to thinner (in the sub-micron scale), more brittle and less elastic fibers. In a nutshell, the results indicated that fiber mats of desired orientation, fiber diameter and mechanical properties could be produced by controlled gap-spinning with a translational collector.
KW - Composite structures
KW - Electrospinning
KW - Extra cellular matrix
KW - Polycaprolactone
KW - Polymers
UR - http://www.scopus.com/inward/record.url?scp=85017501062&partnerID=8YFLogxK
U2 - 10.1007/s12221-016-6256-7
DO - 10.1007/s12221-016-6256-7
M3 - Article
AN - SCOPUS:85017501062
VL - 17
SP - 1025
EP - 1032
JO - Fibers and polymers
JF - Fibers and polymers
SN - 1229-9197
IS - 7
ER -