Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 1700450 |
| Fachzeitschrift | Molecular nutrition & food research |
| Jahrgang | 62 |
| Ausgabenummer | 2 |
| Frühes Online-Datum | 10 Nov. 2017 |
| Publikationsstatus | Veröffentlicht - 22 Jan. 2018 |
Abstract
Scope: Evidence suggests that the dietary consumption of plant extracts containing polyphenols might help prevent the onset of cancers of the gastrointestinal tract. In the present study, the chemopreventive and antiproliferative efficacy of a grapevine shoot extract (Vineatrol®30) containing resveratrol and resveratrol oligomers is investigated in vivo and in vitro.
Methods and results: The in vivo study is performed using Apc Min mice on a high-fat diet, which represents a model of human adenomatous polyposis, while the potential of the extract as well as some of its isolated constituents to inhibit intestinal adenoma cell proliferation in vitro is investigated using APC10.1 cells derived from an Apc Min mouse. Vineatrol®30 at a low (2.3 mg kg –1 diet) or high dose (476 mg kg –1 diet) reduces the adenoma number in male and adenoma volume in female animals. Furthermore, Vineatrol®30 as well as resveratrol and two resveratrol tetramers compromise the expansion of APC10.1 cells by reducing cell number, inducing cell cycle arrest, cellular senescence, and apoptosis. However, except for the extract, none of the isolated resveratrol oligomers is more efficacious than resveratrol in these cells.
Conclusion: Vineatrol®30 may merit further investigation as a potential dietary gastrointestinal cancer chemopreventive agent in humans.
ASJC Scopus Sachgebiete
- Agrar- und Biowissenschaften (insg.)
- Lebensmittelwissenschaften
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biotechnologie
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in: Molecular nutrition & food research, Jahrgang 62, Nr. 2, 1700450, 22.01.2018.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Effects of a Grapevine Shoot Extract Containing Resveratrol and Resveratrol Oligomers on Intestinal Adenoma Development in Mice
T2 - In Vitro and In Vivo Studies
AU - Empl, Michael T.
AU - Cai, Hong
AU - Wang, Shan
AU - Junginger, Johannes ´
AU - Kostka, T
AU - Hewicker-Trautwein, Marion
AU - Brown, Karen
AU - Gescher, Andreas J.
AU - Steinberg, Pablo
N1 - © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/1/22
Y1 - 2018/1/22
N2 - Scope: Evidence suggests that the dietary consumption of plant extracts containing polyphenols might help prevent the onset of cancers of the gastrointestinal tract. In the present study, the chemopreventive and antiproliferative efficacy of a grapevine shoot extract (Vineatrol®30) containing resveratrol and resveratrol oligomers is investigated in vivo and in vitro. Methods and results: The in vivo study is performed using Apc Min mice on a high-fat diet, which represents a model of human adenomatous polyposis, while the potential of the extract as well as some of its isolated constituents to inhibit intestinal adenoma cell proliferation in vitro is investigated using APC10.1 cells derived from an Apc Min mouse. Vineatrol®30 at a low (2.3 mg kg –1 diet) or high dose (476 mg kg –1 diet) reduces the adenoma number in male and adenoma volume in female animals. Furthermore, Vineatrol®30 as well as resveratrol and two resveratrol tetramers compromise the expansion of APC10.1 cells by reducing cell number, inducing cell cycle arrest, cellular senescence, and apoptosis. However, except for the extract, none of the isolated resveratrol oligomers is more efficacious than resveratrol in these cells. Conclusion: Vineatrol®30 may merit further investigation as a potential dietary gastrointestinal cancer chemopreventive agent in humans.
AB - Scope: Evidence suggests that the dietary consumption of plant extracts containing polyphenols might help prevent the onset of cancers of the gastrointestinal tract. In the present study, the chemopreventive and antiproliferative efficacy of a grapevine shoot extract (Vineatrol®30) containing resveratrol and resveratrol oligomers is investigated in vivo and in vitro. Methods and results: The in vivo study is performed using Apc Min mice on a high-fat diet, which represents a model of human adenomatous polyposis, while the potential of the extract as well as some of its isolated constituents to inhibit intestinal adenoma cell proliferation in vitro is investigated using APC10.1 cells derived from an Apc Min mouse. Vineatrol®30 at a low (2.3 mg kg –1 diet) or high dose (476 mg kg –1 diet) reduces the adenoma number in male and adenoma volume in female animals. Furthermore, Vineatrol®30 as well as resveratrol and two resveratrol tetramers compromise the expansion of APC10.1 cells by reducing cell number, inducing cell cycle arrest, cellular senescence, and apoptosis. However, except for the extract, none of the isolated resveratrol oligomers is more efficacious than resveratrol in these cells. Conclusion: Vineatrol®30 may merit further investigation as a potential dietary gastrointestinal cancer chemopreventive agent in humans.
KW - Apc mouse
KW - chemoprevention
KW - grapevine shoot extract
KW - resveratrol
KW - resveratrol oligomers
KW - Intestinal Neoplasms/metabolism
KW - Male
KW - Adenoma/metabolism
KW - Anticarcinogenic Agents/chemistry
KW - Caspases/metabolism
KW - Animals
KW - Mice, Mutant Strains
KW - Antineoplastic Agents, Phytogenic/chemistry
KW - Female
KW - Phenols/chemistry
KW - Resveratrol/chemistry
KW - Stilbenes/pharmacology
KW - Cell Proliferation/drug effects
UR - http://www.scopus.com/inward/record.url?scp=85040829429&partnerID=8YFLogxK
U2 - 10.1002/mnfr.201700450
DO - 10.1002/mnfr.201700450
M3 - Article
C2 - 29125219
VL - 62
JO - Molecular nutrition & food research
JF - Molecular nutrition & food research
SN - 1613-4133
IS - 2
M1 - 1700450
ER -