TY - JOUR

T1 - Effect of PEG functionalization on the saturation magnetization of magnetic nanoporous core-shell nanoparticles

AU - Herrmann, T.

AU - Schierz, A. K.

AU - Prediger, M.

AU - Reifenrath, J.

AU - Meißner, J.

AU - Wurz, M. C.

AU - Behrens, P.

N1 - Funding Information: This work is funded by the DFG (Project number 280642759) in a joint project with Hannover Medical School and the University of Veterinary Medicine Han-nover. It also profits from funding by the DFG under Germany’s Excellence Strategy within the Cluster of Excellence PhoenixD (EXC 2122, Project ID 390833453) and the Cluster of Excellence Hearing4all (EXC 2177, Project ID 390895286). The authors would like to thank the LNQE (Laboratory of Nano and Quantum Engineering, Leibniz University Hannover) for the use of their TEM equipment as well as Songül Noyun and Katharina Petrović for ni-trogen sorption and thermogravimetric measurements, respectively. Furthermore, the authors like to thank Gian Luigi Angrisani (Institute for Materials Science, Leibniz University Hannover) for the preparation of the VSM sample holders.

PY - 2022/3/21

Y1 - 2022/3/21

N2 - The treatment of implant-associated infections is still a considerable issue in modern orthopaedical surgery. A promising candi-date to improve this situation are superparamagnetic, drug-loaded nanoparticles in combination with a magnetizable implant and an external magnetic field. This set-up can enhance the accumulation of the magnetic nanoparticles at the targeted implant, thus reducing the number of nanoparticles needed for a successful treatment. Important prerequisites for the superparamagnet-ic nanoparticles to be used are a high magnetization and a sufficiently long circulation time within the body. A poly(ethyleneglycol) (PEG) functionalization is widely used to increase the circulation time. Since the PEG functionalization adds mass to the nanoparticles and influences also other properties, we functionalized magnetic nanoporous silica nanoparti-cles (MNPSNPs) with PEG moieties of different chain length and studied the effect of the chain length on the saturation magnet-ization of the particles.

AB - The treatment of implant-associated infections is still a considerable issue in modern orthopaedical surgery. A promising candi-date to improve this situation are superparamagnetic, drug-loaded nanoparticles in combination with a magnetizable implant and an external magnetic field. This set-up can enhance the accumulation of the magnetic nanoparticles at the targeted implant, thus reducing the number of nanoparticles needed for a successful treatment. Important prerequisites for the superparamagnet-ic nanoparticles to be used are a high magnetization and a sufficiently long circulation time within the body. A poly(ethyleneglycol) (PEG) functionalization is widely used to increase the circulation time. Since the PEG functionalization adds mass to the nanoparticles and influences also other properties, we functionalized magnetic nanoporous silica nanoparti-cles (MNPSNPs) with PEG moieties of different chain length and studied the effect of the chain length on the saturation magnet-ization of the particles.

UR - http://www.scopus.com/inward/record.url?scp=85128472042&partnerID=8YFLogxK

U2 - 10.18416/ijmpi.2022.2203009

DO - 10.18416/ijmpi.2022.2203009

M3 - Article

AN - SCOPUS:85128472042

VL - 8

JO - International Journal on Magnetic Particle Imaging

JF - International Journal on Magnetic Particle Imaging

SN - 2365-9033

IS - 1

M1 - 2203009

ER -