Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1710-1711 |
| Seitenumfang | 2 |
| Fachzeitschrift | Chemical communications |
| Jahrgang | 1 |
| Ausgabenummer | 18 |
| Publikationsstatus | Veröffentlicht - 1 Jan. 2001 |
| Extern publiziert | Ja |
Abstract
The difluoromethylene analogue of aspartyl phosphate 6 has been prepared by the fluoride catalysed coupling of diethyl trimethylsilyldifluoromethyl phosphonate with an appropriate aldehyde followed by Dess-Martin oxidation and deprotection; the deprotected compound inhibited (KI 95 μM) aspartate semi-aldehyde dehydrogenase, a key enzyme involved in bacterial amino acid and peptidoglycan biosynthesis.
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in: Chemical communications, Jahrgang 1, Nr. 18, 01.01.2001, S. 1710-1711.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Difluoromethylene analogues of aspartyl phosphate
T2 - The first synthetic inhibitors of aspartate semi-aldehyde dehydrogenase
AU - Cox, Russell J.
AU - Hadfield, Andrea T.
AU - Mayo-Martín, M. Belén
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The difluoromethylene analogue of aspartyl phosphate 6 has been prepared by the fluoride catalysed coupling of diethyl trimethylsilyldifluoromethyl phosphonate with an appropriate aldehyde followed by Dess-Martin oxidation and deprotection; the deprotected compound inhibited (KI 95 μM) aspartate semi-aldehyde dehydrogenase, a key enzyme involved in bacterial amino acid and peptidoglycan biosynthesis.
AB - The difluoromethylene analogue of aspartyl phosphate 6 has been prepared by the fluoride catalysed coupling of diethyl trimethylsilyldifluoromethyl phosphonate with an appropriate aldehyde followed by Dess-Martin oxidation and deprotection; the deprotected compound inhibited (KI 95 μM) aspartate semi-aldehyde dehydrogenase, a key enzyme involved in bacterial amino acid and peptidoglycan biosynthesis.
UR - http://www.scopus.com/inward/record.url?scp=0035929198&partnerID=8YFLogxK
U2 - 10.1039/b103988c
DO - 10.1039/b103988c
M3 - Article
C2 - 12240277
AN - SCOPUS:0035929198
VL - 1
SP - 1710
EP - 1711
JO - Chemical communications
JF - Chemical communications
SN - 1359-7345
IS - 18
ER -