TY - JOUR

T1 - Development of Magnesium Alloy Scaffolds to Support Biological Myocardial Grafts

T2 - A Finite Element Investigation

AU - Weidling, Martin

AU - Besdo, Silke

AU - Schilling, Tobias

AU - Bauer, Michael

AU - Hassel, Thomas

AU - Bach, Friedrich Wilhelm

AU - Maier, Hans Jürgen

AU - Lamon, Jacques

AU - Haverich, Axel

AU - Wriggers, Peter

N1 - Funding information: The authors are thankful to the German Research Foundation (DFG) for their financial support. This project is funded within the Collaborative Research Center 599 (SFB 599) and the International Research Training Group 1627 (GRK 1627). Furthermore, we thank Martina Baldrich who developed scaffold shape 7 and Julian Schrader who developed shapes 8–12 in student projects, respectively.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most biological grafts is initially not sufficient for left ventricular applications. Implants that mechanically support these grafts and gradually lose their function as the graft develops its strength are a possible solution. We are developing magnesium alloy scaffolds for this purpose. The finite element method was used to perform simulations wherein scaffolds are deformed according to the heart movement. This allows us to identify highly stressed regions within the implant that need design changes. Preformed scaffolds were determined to have significantly lower stresses in comparison to flat ones. The method of tensile triangles suggests shape changes for notable stress reduction. Furthermore, new scaffold shapes were developed and simulated. Two of them are recommended for further examinations through in vitro and in vivo tests. A completely new alternative scaffold concept is also proposed.

AB - Lesioned myocardial tissue can be replaced with innovative biological grafts. However, the strength of most biological grafts is initially not sufficient for left ventricular applications. Implants that mechanically support these grafts and gradually lose their function as the graft develops its strength are a possible solution. We are developing magnesium alloy scaffolds for this purpose. The finite element method was used to perform simulations wherein scaffolds are deformed according to the heart movement. This allows us to identify highly stressed regions within the implant that need design changes. Preformed scaffolds were determined to have significantly lower stresses in comparison to flat ones. The method of tensile triangles suggests shape changes for notable stress reduction. Furthermore, new scaffold shapes were developed and simulated. Two of them are recommended for further examinations through in vitro and in vivo tests. A completely new alternative scaffold concept is also proposed.

KW - FEM

KW - Heart attack

KW - LA63

KW - Left ventricle

KW - Numerical simulation

KW - Supporting structure

KW - Tensile triangles

KW - Tissue substitution

UR - http://www.scopus.com/inward/record.url?scp=84937545255&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-10981-7_6

DO - 10.1007/978-3-319-10981-7_6

M3 - Article

AN - SCOPUS:84937545255

VL - 74

SP - 81

EP - 100

JO - Lecture Notes in Applied and Computational Mechanics

JF - Lecture Notes in Applied and Computational Mechanics

SN - 1613-7736

ER -