Development and application of a new enzyme sensor type based on the EIS-capacitance structure for bioprocess control

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • M. Beyer
  • C. Menzel
  • R. Quack
  • T. Scheper
  • K. Schügerl
  • W. Treichel
  • H. Voigt
  • M. Ullrich
  • R. Ferretti

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Details

OriginalspracheEnglisch
Seiten (von - bis)17-21
Seitenumfang5
FachzeitschriftBiosensors and Bioelectronics
Jahrgang9
Ausgabenummer1
PublikationsstatusVeröffentlicht - 1994

Abstract

New biosensors were developed by immobilizing enzymes on simple EIS (Electrolyte Insulator Semiconductor) layer structures. These EIS-structures produced by means of semiconductor technologies are either pH-(Si/SiO2/Si3N4/Ta2O5 layers) or pF-sensitive (Si/SiO2/Si3N4/LaF3 layers). A schematic of the layered structure is shown in Fig. 1. The basic principle for measurements with the modified EIS-layer structures is the change in capacitance in dependence on the concentration of H+ or F- ions. Measurements were made by using a C/V-measuring instrument in a "constant charge mode". These biosensors as well as a reference electrode were integrated into an FIA-system (Flow Injection Analyser) and the concentrations of penicillin and urea (with pH-sensor) and H2O2 and glucose (with pF-sensor) were determined.

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Development and application of a new enzyme sensor type based on the EIS-capacitance structure for bioprocess control. / Beyer, M.; Menzel, C.; Quack, R. et al.
in: Biosensors and Bioelectronics, Jahrgang 9, Nr. 1, 1994, S. 17-21.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Beyer M, Menzel C, Quack R, Scheper T, Schügerl K, Treichel W et al. Development and application of a new enzyme sensor type based on the EIS-capacitance structure for bioprocess control. Biosensors and Bioelectronics. 1994;9(1):17-21. doi: 10.1016/0956-5663(94)80010-3
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abstract = "New biosensors were developed by immobilizing enzymes on simple EIS (Electrolyte Insulator Semiconductor) layer structures. These EIS-structures produced by means of semiconductor technologies are either pH-(Si/SiO2/Si3N4/Ta2O5 layers) or pF-sensitive (Si/SiO2/Si3N4/LaF3 layers). A schematic of the layered structure is shown in Fig. 1. The basic principle for measurements with the modified EIS-layer structures is the change in capacitance in dependence on the concentration of H+ or F- ions. Measurements were made by using a C/V-measuring instrument in a {"}constant charge mode{"}. These biosensors as well as a reference electrode were integrated into an FIA-system (Flow Injection Analyser) and the concentrations of penicillin and urea (with pH-sensor) and H2O2 and glucose (with pF-sensor) were determined.",
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T1 - Development and application of a new enzyme sensor type based on the EIS-capacitance structure for bioprocess control

AU - Beyer, M.

AU - Menzel, C.

AU - Quack, R.

AU - Scheper, T.

AU - Schügerl, K.

AU - Treichel, W.

AU - Voigt, H.

AU - Ullrich, M.

AU - Ferretti, R.

PY - 1994

Y1 - 1994

N2 - New biosensors were developed by immobilizing enzymes on simple EIS (Electrolyte Insulator Semiconductor) layer structures. These EIS-structures produced by means of semiconductor technologies are either pH-(Si/SiO2/Si3N4/Ta2O5 layers) or pF-sensitive (Si/SiO2/Si3N4/LaF3 layers). A schematic of the layered structure is shown in Fig. 1. The basic principle for measurements with the modified EIS-layer structures is the change in capacitance in dependence on the concentration of H+ or F- ions. Measurements were made by using a C/V-measuring instrument in a "constant charge mode". These biosensors as well as a reference electrode were integrated into an FIA-system (Flow Injection Analyser) and the concentrations of penicillin and urea (with pH-sensor) and H2O2 and glucose (with pF-sensor) were determined.

AB - New biosensors were developed by immobilizing enzymes on simple EIS (Electrolyte Insulator Semiconductor) layer structures. These EIS-structures produced by means of semiconductor technologies are either pH-(Si/SiO2/Si3N4/Ta2O5 layers) or pF-sensitive (Si/SiO2/Si3N4/LaF3 layers). A schematic of the layered structure is shown in Fig. 1. The basic principle for measurements with the modified EIS-layer structures is the change in capacitance in dependence on the concentration of H+ or F- ions. Measurements were made by using a C/V-measuring instrument in a "constant charge mode". These biosensors as well as a reference electrode were integrated into an FIA-system (Flow Injection Analyser) and the concentrations of penicillin and urea (with pH-sensor) and H2O2 and glucose (with pF-sensor) were determined.

KW - C/V measurements

KW - EIS-structures

KW - enzyme sensor

KW - FIA-system

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U2 - 10.1016/0956-5663(94)80010-3

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