Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 78-86 |
| Seitenumfang | 9 |
| Fachzeitschrift | Molecular and Cellular Endocrinology |
| Jahrgang | 348 |
| Ausgabenummer | 1 |
| Publikationsstatus | Veröffentlicht - 2 Jan. 2012 |
| Extern publiziert | Ja |
Abstract
This study was aimed to test our hypothesis that the developing brain operates as an endocrine organ before the establishment of the blood-brain barrier (BBB), in rats up to the first postnatal week. Dopamine (DA) was selected as a marker of the brain endocrine activity. The hypothesis was supported by the observations in rats of: (i) the physiological concentration of DA in peripheral blood of fetuses and neonates, before the BBB establishment, and its drop by prepubertal period, after the BBB development; (ii) a drop of the DA concentration in the brain for 54% and in blood for 74% on the 3rd postnatal day after the intraventricular administration of 50μg of α-methyl-p-tyrosine, an inhibitor of DA synthesis, with no changes in the DA metabolism in peripheral DA-producing organs. Thus, the developing brain is a principal source of circulating DA which is capable of providing an endocrine regulation of peripheral organs and the brain.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularbiologie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Endokrinologie
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
in: Molecular and Cellular Endocrinology, Jahrgang 348, Nr. 1, 02.01.2012, S. 78-86.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Developing brain as an endocrine organ
T2 - Secretion of dopamine
AU - Ugrumov, Michael V.
AU - Saifetyarova, Julia Y.
AU - Lavrentieva, Antonina V.
AU - Sapronova, Anna Y.
N1 - Funding Information: The present study was supported by the following Grants: Program of the Basic Research, Department of Biological Sciences of the Russian Academy of Sciences “Integrative mechanisms of the functional regulations in the organism”, RFBR-08-04-01084 , RFBR-CNRS-07-04-92173 , RFBR-OBR-09-04-13851 , RFBR-CNRS-10-04-93108 , RFBR-11-04-01840 . Copyright: Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/1/2
Y1 - 2012/1/2
N2 - This study was aimed to test our hypothesis that the developing brain operates as an endocrine organ before the establishment of the blood-brain barrier (BBB), in rats up to the first postnatal week. Dopamine (DA) was selected as a marker of the brain endocrine activity. The hypothesis was supported by the observations in rats of: (i) the physiological concentration of DA in peripheral blood of fetuses and neonates, before the BBB establishment, and its drop by prepubertal period, after the BBB development; (ii) a drop of the DA concentration in the brain for 54% and in blood for 74% on the 3rd postnatal day after the intraventricular administration of 50μg of α-methyl-p-tyrosine, an inhibitor of DA synthesis, with no changes in the DA metabolism in peripheral DA-producing organs. Thus, the developing brain is a principal source of circulating DA which is capable of providing an endocrine regulation of peripheral organs and the brain.
AB - This study was aimed to test our hypothesis that the developing brain operates as an endocrine organ before the establishment of the blood-brain barrier (BBB), in rats up to the first postnatal week. Dopamine (DA) was selected as a marker of the brain endocrine activity. The hypothesis was supported by the observations in rats of: (i) the physiological concentration of DA in peripheral blood of fetuses and neonates, before the BBB establishment, and its drop by prepubertal period, after the BBB development; (ii) a drop of the DA concentration in the brain for 54% and in blood for 74% on the 3rd postnatal day after the intraventricular administration of 50μg of α-methyl-p-tyrosine, an inhibitor of DA synthesis, with no changes in the DA metabolism in peripheral DA-producing organs. Thus, the developing brain is a principal source of circulating DA which is capable of providing an endocrine regulation of peripheral organs and the brain.
KW - Blood-brain barrier
KW - Brain
KW - Development
KW - Dopamine
KW - Neuron
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=80755163599&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2011.07.038
DO - 10.1016/j.mce.2011.07.038
M3 - Article
C2 - 21827827
AN - SCOPUS:80755163599
VL - 348
SP - 78
EP - 86
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1
ER -