Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 1013 |
| Seiten (von - bis) | 1-8 |
| Seitenumfang | 8 |
| Fachzeitschrift | CATALYSTS |
| Jahrgang | 10 |
| Ausgabenummer | 9 |
| Publikationsstatus | Veröffentlicht - 3 Sept. 2020 |
| Extern publiziert | Ja |
Abstract
Alcohol dehydrogenase (ADH) catalyzed reductions in deep eutectic solvents (DESs) may become efficient and sustainable alternatives to afford alcohols. This paper successfully explores the ADH-catalyzed reduction of ketones and aldehydes in a DES composed of choline chloride and 1,4-butanediol, in combination with buffer (Tris-HCl, 20% v/v). 1,4-butanediol (a DES component), acts as a smart cosubstrate for the enzymatic cofactor regeneration, shifting the thermodynamic equilibrium to the product side. By means of the novel DES media, cyclohexanone reduction was optimized to yield maximum productivity with low enzyme amounts (in the range of 10 g L−1 d−1). Notably, with the herein developed reaction media, cinnamaldehyde was reduced to cinnamyl alcohol, an important compound for the fragrance industry, with promising high productivities of ~75 g L−1 d−1.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
- Physikalische und Theoretische Chemie
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in: CATALYSTS, Jahrgang 10, Nr. 9, 1013, 03.09.2020, S. 1-8.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Deep Eutectic Solvents as Smart Cosubstrate in Alcohol Dehydrogenase-Catalyzed Reductions
AU - Chanquia, Santiago Nahuel
AU - Huang, Lei
AU - Liñares, Guadalupe García
AU - de María, Pablo Domínguez
AU - Kara, Selin
N1 - Funding Information: Funding: This work was funded by Deutsche Forschungsgemeinschaft (DFG) grant number: KA 4399/3-1 and Aarhus Universitets Forskningsfond (AUFF) Starting Grant.
PY - 2020/9/3
Y1 - 2020/9/3
N2 - Alcohol dehydrogenase (ADH) catalyzed reductions in deep eutectic solvents (DESs) may become efficient and sustainable alternatives to afford alcohols. This paper successfully explores the ADH-catalyzed reduction of ketones and aldehydes in a DES composed of choline chloride and 1,4-butanediol, in combination with buffer (Tris-HCl, 20% v/v). 1,4-butanediol (a DES component), acts as a smart cosubstrate for the enzymatic cofactor regeneration, shifting the thermodynamic equilibrium to the product side. By means of the novel DES media, cyclohexanone reduction was optimized to yield maximum productivity with low enzyme amounts (in the range of 10 g L−1 d−1). Notably, with the herein developed reaction media, cinnamaldehyde was reduced to cinnamyl alcohol, an important compound for the fragrance industry, with promising high productivities of ~75 g L−1 d−1.
AB - Alcohol dehydrogenase (ADH) catalyzed reductions in deep eutectic solvents (DESs) may become efficient and sustainable alternatives to afford alcohols. This paper successfully explores the ADH-catalyzed reduction of ketones and aldehydes in a DES composed of choline chloride and 1,4-butanediol, in combination with buffer (Tris-HCl, 20% v/v). 1,4-butanediol (a DES component), acts as a smart cosubstrate for the enzymatic cofactor regeneration, shifting the thermodynamic equilibrium to the product side. By means of the novel DES media, cyclohexanone reduction was optimized to yield maximum productivity with low enzyme amounts (in the range of 10 g L−1 d−1). Notably, with the herein developed reaction media, cinnamaldehyde was reduced to cinnamyl alcohol, an important compound for the fragrance industry, with promising high productivities of ~75 g L−1 d−1.
KW - Alcohol dehydrogenases
KW - Cinnamyl alcohol
KW - Deep eutectic solvents
KW - Reductions
KW - Smart cosubstrate
UR - http://www.scopus.com/inward/record.url?scp=85090522182&partnerID=8YFLogxK
U2 - 10.3390/catal10091013
DO - 10.3390/catal10091013
M3 - Article
AN - SCOPUS:85090522182
VL - 10
SP - 1
EP - 8
JO - CATALYSTS
JF - CATALYSTS
SN - 2073-4344
IS - 9
M1 - 1013
ER -