Details
| Titel in Übersetzung | The stressful life of Bacillus subtilis |
|---|---|
| Originalsprache | Deutsch |
| Seiten (von - bis) | 150-152 |
| Seitenumfang | 3 |
| Fachzeitschrift | BioSpektrum |
| Jahrgang | 25 |
| Ausgabenummer | 2 |
| Frühes Online-Datum | 26 März 2019 |
| Publikationsstatus | Veröffentlicht - 1 Apr. 2019 |
Abstract
Here we present Bacillus subtilis as a model system to study protein homeostasis and protein quality control in conjunction with the different layers of its stress response systems. We established a new marker to study protein aggregation in vivo. Furthermore, we observed that the transcription factor Spx, which has already been characterized as a central player to activate transcription of redox-chaperones during heat shock and oxidative stress response, was also able to simultaneously inhibit the transcription of translation-related genes as a second response to stress.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biotechnologie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularbiologie
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in: BioSpektrum, Jahrgang 25, Nr. 2, 01.04.2019, S. 150-152.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung
}
TY - JOUR
T1 - Das stressige Leben des Bacillus subtilis
AU - Hantke, Ingo
AU - Schäfer, Heinrich
AU - Kramer, Regina
AU - Turgay, Kürşad
N1 - Publisher Copyright: © 2019, Springer-Verlag. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Here we present Bacillus subtilis as a model system to study protein homeostasis and protein quality control in conjunction with the different layers of its stress response systems. We established a new marker to study protein aggregation in vivo. Furthermore, we observed that the transcription factor Spx, which has already been characterized as a central player to activate transcription of redox-chaperones during heat shock and oxidative stress response, was also able to simultaneously inhibit the transcription of translation-related genes as a second response to stress.
AB - Here we present Bacillus subtilis as a model system to study protein homeostasis and protein quality control in conjunction with the different layers of its stress response systems. We established a new marker to study protein aggregation in vivo. Furthermore, we observed that the transcription factor Spx, which has already been characterized as a central player to activate transcription of redox-chaperones during heat shock and oxidative stress response, was also able to simultaneously inhibit the transcription of translation-related genes as a second response to stress.
UR - http://www.scopus.com/inward/record.url?scp=85063568979&partnerID=8YFLogxK
U2 - 10.1007/s12268-019-1023-0
DO - 10.1007/s12268-019-1023-0
M3 - Artikel
AN - SCOPUS:85063568979
VL - 25
SP - 150
EP - 152
JO - BioSpektrum
JF - BioSpektrum
SN - 0947-0867
IS - 2
ER -