Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by actinosynnema pretiosum as biocatalyst

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  • Helmholtz-Zentrum für Infektionsforschung GmbH (HZI)
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OriginalspracheEnglisch
Seiten (von - bis)2517-2520
Seitenumfang4
FachzeitschriftChemBioChem
Jahrgang11
Ausgabenummer18
PublikationsstatusVeröffentlicht - 10 Dez. 2010

Abstract

Ring closure is possible with seco-proansamitocin and two activated SNAC esters, which can be processed to ansamitocin P3 and 19-deschloro-20-demethoxy AP-3, respectively, by an AHBA-blocked mutant of Actinosynnema pretiosum. This work sheds light on the synthetic potential of macrolactamizing amide synthases. The new ansamitocin derivative showed similar to enhanced antiproliferative activity against several cancer cell lines relative to AP-3.

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Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by actinosynnema pretiosum as biocatalyst. / Harmrolfs, Kirsten; Brünjes, Marco; Dräger, Gerald et al.
in: ChemBioChem, Jahrgang 11, Nr. 18, 10.12.2010, S. 2517-2520.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Harmrolfs K, Brünjes M, Dräger G, Floss HG, Sasse F, Taft F et al. Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by actinosynnema pretiosum as biocatalyst. ChemBioChem. 2010 Dez 10;11(18):2517-2520. doi: 10.1002/cbic.201000422
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T1 - Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by actinosynnema pretiosum as biocatalyst

AU - Harmrolfs, Kirsten

AU - Brünjes, Marco

AU - Dräger, Gerald

AU - Floss, Heinz G.

AU - Sasse, Florenz

AU - Taft, Florian

AU - Kirschning, Andreas

PY - 2010/12/10

Y1 - 2010/12/10

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KW - Ansamitocin

KW - Mutabiosynthesis

KW - SNAC esters

KW - Total synthesis

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