TY - JOUR

T1 - Cyclic Dinucleotide-Controlled Regulatory Pathways in Streptomyces Species

AU - Tschowri, Natalia

N1 - Publisher Copyright: © 2015, American Society for Microbiology. All Rights Reserved. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The cyclic dinucleotides cyclic 3′,5′-diguanylate (c-di-GMP) and cyclic 3′,5′-diadenylate (c-di-AMP) have emerged as key components of bacterial signal transduction networks. These closely related second messengers follow the classical general principles of nucleotide signaling by integrating diverse signals into regulatory pathways that control cellular responses to changing environments. They impact distinct cellular processes, with c-di-GMP having an established role in promoting bacterial adhesion and inhibiting motility and c-di-AMP being involved in cell wall metabolism, potassium homeostasis, and DNA repair. The involvement of c-dinucleotides in the physiology of the filamentous, nonmotile streptomycetes remained obscure until recent discoveries showed that c-di-GMP controls the activity of the developmental master regulator BldD and that c-di-AMP determines the level of the resuscitation-promoting factor A(RpfA) cell wall-remodelling enzyme. Here, I summarize our current knowledge of c-dinucleotide signaling in Streptomyces species and highlight the important roles of c-di-GMP and c-di-AMP in the biology of these antibiotic-producing, multicellular bacteria.

AB - The cyclic dinucleotides cyclic 3′,5′-diguanylate (c-di-GMP) and cyclic 3′,5′-diadenylate (c-di-AMP) have emerged as key components of bacterial signal transduction networks. These closely related second messengers follow the classical general principles of nucleotide signaling by integrating diverse signals into regulatory pathways that control cellular responses to changing environments. They impact distinct cellular processes, with c-di-GMP having an established role in promoting bacterial adhesion and inhibiting motility and c-di-AMP being involved in cell wall metabolism, potassium homeostasis, and DNA repair. The involvement of c-dinucleotides in the physiology of the filamentous, nonmotile streptomycetes remained obscure until recent discoveries showed that c-di-GMP controls the activity of the developmental master regulator BldD and that c-di-AMP determines the level of the resuscitation-promoting factor A(RpfA) cell wall-remodelling enzyme. Here, I summarize our current knowledge of c-dinucleotide signaling in Streptomyces species and highlight the important roles of c-di-GMP and c-di-AMP in the biology of these antibiotic-producing, multicellular bacteria.

KW - Bacterial Proteins/genetics

KW - Cyclic GMP/analogs & derivatives

KW - Gene Expression Regulation, Bacterial/physiology

KW - Signal Transduction/physiology

KW - Species Specificity

KW - Streptomyces/physiology

UR - http://www.scopus.com/inward/record.url?scp=84953896752&partnerID=8YFLogxK

U2 - 10.1128/JB.00423-15

DO - 10.1128/JB.00423-15

M3 - Article

C2 - 26216850

VL - 198

SP - 47

EP - 54

JO - Journal of bacteriology

JF - Journal of bacteriology

SN - 0021-9193

IS - 1

ER -