Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 9-27 |
| Seitenumfang | 19 |
| Fachzeitschrift | Natural Product Reports |
| Jahrgang | 40 |
| Ausgabenummer | 1 |
| Publikationsstatus | Veröffentlicht - 11 Mai 2022 |
Abstract
Covering: 1996-2022Investigations over the last 2 decades have begun to reveal how fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in vivo experiments have revealed the interplay of intrinsic and extrinsic selectivity of the component catalytic domains of these systems. Structural biology has begun to provide high resolution structures of hr-PKS that can be used as the basis for their engineering and reprogramming, but progress to-date remains rudimentary. However, significant opportunities exist for translating the current level of understanding into the ability to rationally re-engineer these highly efficient systems for the production of important biologically active compounds through biotechnology.
ASJC Scopus Sachgebiete
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Wirkstoffforschung
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Chemie (insg.)
- Organische Chemie
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in: Natural Product Reports, Jahrgang 40, Nr. 1, 11.05.2022, S. 9-27.
Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review
}
TY - JOUR
T1 - Curiouser and curiouser
T2 - progress in understanding the programming of iterative highly-reducing polyketide synthases
AU - Cox, Russell J.
PY - 2022/5/11
Y1 - 2022/5/11
N2 - Covering: 1996-2022Investigations over the last 2 decades have begun to reveal how fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in vivo experiments have revealed the interplay of intrinsic and extrinsic selectivity of the component catalytic domains of these systems. Structural biology has begun to provide high resolution structures of hr-PKS that can be used as the basis for their engineering and reprogramming, but progress to-date remains rudimentary. However, significant opportunities exist for translating the current level of understanding into the ability to rationally re-engineer these highly efficient systems for the production of important biologically active compounds through biotechnology.
AB - Covering: 1996-2022Investigations over the last 2 decades have begun to reveal how fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in vivo experiments have revealed the interplay of intrinsic and extrinsic selectivity of the component catalytic domains of these systems. Structural biology has begun to provide high resolution structures of hr-PKS that can be used as the basis for their engineering and reprogramming, but progress to-date remains rudimentary. However, significant opportunities exist for translating the current level of understanding into the ability to rationally re-engineer these highly efficient systems for the production of important biologically active compounds through biotechnology.
UR - http://www.scopus.com/inward/record.url?scp=85147318142&partnerID=8YFLogxK
U2 - 10.1039/D2NP00007E
DO - 10.1039/D2NP00007E
M3 - Review article
VL - 40
SP - 9
EP - 27
JO - Natural Product Reports
JF - Natural Product Reports
SN - 0265-0568
IS - 1
ER -