Contiguous Quaternary Carbons: A Selection of Total Syntheses

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Alina Eggert
  • Christoph Etling
  • Dennis Lübken
  • Marius Saxarra
  • Markus Kalesse

Organisationseinheiten

Externe Organisationen

  • Helmholtz-Zentrum für Infektionsforschung GmbH (HZI)
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Aufsatznummer3841
FachzeitschriftMOLECULES
Jahrgang25
Ausgabenummer17
Frühes Online-Datum24 Aug. 2020
PublikationsstatusVeröffentlicht - Sept. 2020

Abstract

Contiguous quaternary carbons in terpene natural products remain a major challenge in total synthesis. Synthetic strategies to overcome this challenge will be a pivotal prerequisite to the medicinal application of natural products and their analogs or derivatives. In this review, we cover syntheses of natural products that exhibit a dense assembly of quaternary carbons and whose syntheses were uncompleted until recently. While discussing their syntheses, we not only cover the most recent total syntheses but also provide an update on the status quo of modern syntheses of complex natural products. Herein, we review (±)-canataxpropellane, (+)-waihoensene, (–)-illisimonin A and (±)-11-O-debenzoyltashironin as prominent examples of natural products bearing contiguous quaternary carbons.

ASJC Scopus Sachgebiete

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Contiguous Quaternary Carbons: A Selection of Total Syntheses. / Eggert, Alina; Etling, Christoph; Lübken, Dennis et al.
in: MOLECULES, Jahrgang 25, Nr. 17, 3841, 09.2020.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Eggert A, Etling C, Lübken D, Saxarra M, Kalesse M. Contiguous Quaternary Carbons: A Selection of Total Syntheses. MOLECULES. 2020 Sep;25(17):3841. Epub 2020 Aug 24. doi: 10.3390/molecules25173841
Eggert, Alina ; Etling, Christoph ; Lübken, Dennis et al. / Contiguous Quaternary Carbons : A Selection of Total Syntheses. in: MOLECULES. 2020 ; Jahrgang 25, Nr. 17.
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AU - Eggert, Alina

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AU - Lübken, Dennis

AU - Saxarra, Marius

AU - Kalesse, Markus

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