TY - JOUR

T1 - Comparison of degradation behaviour and osseointegration of the two magnesium scaffolds, LAE442 and La2, in vivo

AU - Kleer, N.

AU - Julmi, Stefan Michael

AU - Gartzke, Ann-Kathrin Sigrid Elisabeth

AU - Augustin, J.

AU - Feichtner, F.

AU - Waselau, Anja Christina

AU - Klose, Christian

AU - Maier, Hans Jürgen

AU - Wriggers, Peter

AU - Meyer-Lindenberg, Andrea

N1 - Funding information: This research was funded by the German Research Foundation (DFG) within the project “Interfacial effects and integration behaviour of magnesium-based sponges as bioresorbable bone substitute material” (Grant No. 271761343). The authors gratefully appreciate the financial support. Moreover, the authors thank Lisa Wurm and Beatrix Limmer for excellent technical support.

PY - 2019/12

Y1 - 2019/12

N2 - Porous magnesium implants have been investigated for some time for their orthopaedic applicability as resorbable bone substitutes. The objective of this study was to evaluate the in vivo degradation behaviour and osseointegration of open-pored scaffolds made of the two magnesium alloys, LAE442 (n = 40) and Mg-La2 (n = 40). Cylindrical magnesium scaffolds (diameter 4 mm, length 5 mm) with defined interconnecting pore structure were produced by investment casting and coated with MgF2. Commercially available porous ß-tricalcium phosphate scaffolds (TCP, n = 40) of the same dimensions served as control. The scaffolds were inserted in the cancellous part of the greater trochanter of both femurs in rabbits and evaluated over a period of 36 weeks using regular clinical, radiological and in vivo µCT examinations. No clinical adverse reactions were observed in any of the scaffolds. The X-ray and µCT image evaluation of La2 showed fast and inhomogeneous degradation behaviour with increased gas formation and a rapid loss of scaffold structure and shape from week 12 on. In comparison, the LAE442 scaffolds showed a slow, homogeneous degradation with low but continuous gas production over the entire study period. Furthermore, LAE442 scaffolds showed comparatively better osseointegration with more trabecular contacts than La2 scaffolds and retained their original scaffold structure. Although the TCP control group demonstrated the best osseointegration, it showed overly-rapid degradation. Based on the results of this study, the LAE422 scaffolds have promising properties for further investigations in weight-bearing bone defects.

AB - Porous magnesium implants have been investigated for some time for their orthopaedic applicability as resorbable bone substitutes. The objective of this study was to evaluate the in vivo degradation behaviour and osseointegration of open-pored scaffolds made of the two magnesium alloys, LAE442 (n = 40) and Mg-La2 (n = 40). Cylindrical magnesium scaffolds (diameter 4 mm, length 5 mm) with defined interconnecting pore structure were produced by investment casting and coated with MgF2. Commercially available porous ß-tricalcium phosphate scaffolds (TCP, n = 40) of the same dimensions served as control. The scaffolds were inserted in the cancellous part of the greater trochanter of both femurs in rabbits and evaluated over a period of 36 weeks using regular clinical, radiological and in vivo µCT examinations. No clinical adverse reactions were observed in any of the scaffolds. The X-ray and µCT image evaluation of La2 showed fast and inhomogeneous degradation behaviour with increased gas formation and a rapid loss of scaffold structure and shape from week 12 on. In comparison, the LAE442 scaffolds showed a slow, homogeneous degradation with low but continuous gas production over the entire study period. Furthermore, LAE442 scaffolds showed comparatively better osseointegration with more trabecular contacts than La2 scaffolds and retained their original scaffold structure. Although the TCP control group demonstrated the best osseointegration, it showed overly-rapid degradation. Based on the results of this study, the LAE422 scaffolds have promising properties for further investigations in weight-bearing bone defects.

KW - Biodegradable implants

KW - Magnesium alloy

KW - Micro-tomography

KW - Osseointegration

KW - Porous scaffolds

UR - http://www.scopus.com/inward/record.url?scp=85070768889&partnerID=8YFLogxK

U2 - 10.1016/j.mtla.2019.100436

DO - 10.1016/j.mtla.2019.100436

M3 - Article

AN - SCOPUS:85070768889

VL - 8

JO - Acta Materialia

JF - Acta Materialia

SN - 1359-6454

M1 - 100436

ER -