TY - JOUR

T1 - Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools

AU - Farag, Mohamed A.

AU - Kabbash, Eman M.

AU - Mediani, Ahmed

AU - Döll, Stefanie

AU - Esatbeyoglu, Tuba

AU - Afifi, Sherif M.

N1 - Funding Information: Funding: The publication of this article was funded by the Open Access Fund of Leibniz Universität Hannover.

PY - 2022/5/4

Y1 - 2022/5/4

N2 - The present study aimed to assess metabolites heterogeneity among four major Cin-namomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cas-sia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocy-anidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum versus procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS analysis en-compassing different classes, viz. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species.

AB - The present study aimed to assess metabolites heterogeneity among four major Cin-namomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cas-sia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocy-anidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum versus procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS analysis en-compassing different classes, viz. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species.

KW - chemometrics

KW - Cinnamomum

KW - erythritol

KW - metabolomics

KW - proanthocyanidin

UR - http://www.scopus.com/inward/record.url?scp=85130056694&partnerID=8YFLogxK

U2 - 10.3390/molecules27092935

DO - 10.3390/molecules27092935

M3 - Article

VL - 27

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 9

M1 - 2935

ER -