TY - JOUR

T1 - Comparative measurements of bone mineral density and bone contrast values in canine femora using dual-energy X-ray absorptiometry and conventional digital radiography

AU - Lucas, K.

AU - Nolte, I.

AU - Galindo-Zamora, V.

AU - Lerch, M.

AU - Stukenborg-Colsman, C.

AU - Behrens, B. A.

AU - Bouguecha, A.

AU - Betancur, S.

AU - Almohallami, A.

AU - Wefstaedt, P.

N1 - Funding information: This study was performed in association with the subproject D6 of the collaborative research center 599: “Sustainable degradable and permanent implants out of metallic and ceramic materials”. The authors wish to thank the German Research Foundation (DFG) for its financial support.

PY - 2017/5/11

Y1 - 2017/5/11

N2 - Background: Aseptic loosening due to bone remodelling processes after total hip replacement is one common cause for revision surgery. In human medicine, dual-energy X-ray absorptiometry (DEXA) is the gold standard for quantitative evaluation of bone mineral density, whereas in veterinary medicine conventional radiography is used for follow-up studies. Recently, a method has been described using digital X-ray images for quantitative assessment of grey scale values of bone contrast. Therefore, the aim of the present study was to evaluate the correlation of bone mineral density (BMD) measured by DEXA with grey scale values (GV) measured in digital X-ray images (RX50, RX66) ex vivo. Results: The measured GV in the chosen X-ray settings showed on average a good correlation (r = 0.61) to the measured BMD with DEXA. Correlation between the two X-ray settings was very good (r = 0.81). For comparisons among regions of interests (ROIs) a difference of 8.2% was found to be statistically significant, whereas in the case of RX50 and RX66 differences of 5.3% and 4.1% were found to be statistically significant. Conclusions: Results indicate that measuring absolute changes in bone mineral density might be possible using digital radiography. Not all significant differences between ROIs detectable with DEXA can be displayed in the X-ray images because of the lower sensitivity of the radiographs. However, direct comparison of grey scale values of the periprosthetic femur in one individual patient during the follow-up period, in order to predict bone remodelling processes, should be possible, but with a lesser sensitivity than with DEXA. It is important that the same X-ray settings are chosen for each patient for follow-up studies.

AB - Background: Aseptic loosening due to bone remodelling processes after total hip replacement is one common cause for revision surgery. In human medicine, dual-energy X-ray absorptiometry (DEXA) is the gold standard for quantitative evaluation of bone mineral density, whereas in veterinary medicine conventional radiography is used for follow-up studies. Recently, a method has been described using digital X-ray images for quantitative assessment of grey scale values of bone contrast. Therefore, the aim of the present study was to evaluate the correlation of bone mineral density (BMD) measured by DEXA with grey scale values (GV) measured in digital X-ray images (RX50, RX66) ex vivo. Results: The measured GV in the chosen X-ray settings showed on average a good correlation (r = 0.61) to the measured BMD with DEXA. Correlation between the two X-ray settings was very good (r = 0.81). For comparisons among regions of interests (ROIs) a difference of 8.2% was found to be statistically significant, whereas in the case of RX50 and RX66 differences of 5.3% and 4.1% were found to be statistically significant. Conclusions: Results indicate that measuring absolute changes in bone mineral density might be possible using digital radiography. Not all significant differences between ROIs detectable with DEXA can be displayed in the X-ray images because of the lower sensitivity of the radiographs. However, direct comparison of grey scale values of the periprosthetic femur in one individual patient during the follow-up period, in order to predict bone remodelling processes, should be possible, but with a lesser sensitivity than with DEXA. It is important that the same X-ray settings are chosen for each patient for follow-up studies.

KW - Bone mineral density

KW - Bone remodelling

KW - Canine

KW - DEXA

KW - Digital radiography

KW - Femur

UR - http://www.scopus.com/inward/record.url?scp=85019127579&partnerID=8YFLogxK

U2 - 10.1186/s12917-017-1047-y

DO - 10.1186/s12917-017-1047-y

M3 - Article

C2 - 28490330

AN - SCOPUS:85019127579

VL - 13

JO - BMC veterinary research

JF - BMC veterinary research

SN - 1746-6148

IS - 1

M1 - 130

ER -