TY - JOUR

T1 - Comparative Investigation of Bone Mineral Density Using CT and DEXA in a Canine Femoral Model

AU - Lucas, Karin

AU - Behrens, Bernd Arno

AU - Nolte, Ingo

AU - Galindo-Zamora, Vladimir

AU - Betancur, Stefanie

AU - Almohallami, Amer

AU - Bouguecha, Anas

AU - Mostafa, Ayman

AU - Lerch, Matthias

AU - Stukenborg-Colsman, Christina

AU - Wefstaedt, Patrick

N1 - Funding information: This study was performed in association with the subproject D6 of the Collaborative Research Center 599 “Sustainable degradable and permanent implants out of metallic and ceramic materials.” The authors wish to thank the German Research Foundation (DFG) for providing financial support.

PY - 2017/4/7

Y1 - 2017/4/7

N2 - Bone density measurements using computed tomography (CT) instead of dual-energy X-ray absorptiometry (DEXA) are currently of great interest in human and veterinary medical research as it would be beneficial to use CT scans obtained for other indications also for determining bone density. For Hounsfield units (HU) measured with CT in specific regions of interests (ROIs) in one or several slice/s a correlation with bone mineral density (BMD) measured by DEXA in humans and dogs of between 0.44 and 0.77 is reported in the literature. In the present study, instead certain volumes of interest (VOIs) obtained by CT scan and the corresponding HU to the respective VOIs were compared with the bone mineral density of the corresponding areas measured by DEXA. The aim of the study was to investigate whether this procedure gives more accurate information about bone density of the bones as three-dimensional objects of the respective patient. Correlation between measured HU in the respective VOI and BMD measured with DEXA in the corresponding ROI showed a very good correlation of 0.93. Linear regression with R2 = 0.85 (p = 0.0262) was calculated. Except for VOI5, similar distribution of values and significant differences (p < 0.0001–0.0087) between ROIs/VOIs were detected. Determining HU for assessing bone mineral density in a certain volume provides more accurate results than those previously reported from two-dimensional (2D) CT measurements.

AB - Bone density measurements using computed tomography (CT) instead of dual-energy X-ray absorptiometry (DEXA) are currently of great interest in human and veterinary medical research as it would be beneficial to use CT scans obtained for other indications also for determining bone density. For Hounsfield units (HU) measured with CT in specific regions of interests (ROIs) in one or several slice/s a correlation with bone mineral density (BMD) measured by DEXA in humans and dogs of between 0.44 and 0.77 is reported in the literature. In the present study, instead certain volumes of interest (VOIs) obtained by CT scan and the corresponding HU to the respective VOIs were compared with the bone mineral density of the corresponding areas measured by DEXA. The aim of the study was to investigate whether this procedure gives more accurate information about bone density of the bones as three-dimensional objects of the respective patient. Correlation between measured HU in the respective VOI and BMD measured with DEXA in the corresponding ROI showed a very good correlation of 0.93. Linear regression with R2 = 0.85 (p = 0.0262) was calculated. Except for VOI5, similar distribution of values and significant differences (p < 0.0001–0.0087) between ROIs/VOIs were detected. Determining HU for assessing bone mineral density in a certain volume provides more accurate results than those previously reported from two-dimensional (2D) CT measurements.

KW - bone mineral density

KW - canine femur

KW - computed tomography

KW - DEXA

KW - volume of interest

UR - http://www.scopus.com/inward/record.url?scp=85018273098&partnerID=8YFLogxK

U2 - 10.1002/jor.23574

DO - 10.1002/jor.23574

M3 - Article

C2 - 28387962

AN - SCOPUS:85018273098

VL - 35

SP - 2667

EP - 2672

JO - Journal of orthopaedic research

JF - Journal of orthopaedic research

SN - 0736-0266

IS - 12

ER -