Details
| Titel in Übersetzung | Coenzyme und ihre Rolle in der Evolution des Lebens |
|---|---|
| Originalsprache | Englisch |
| Seiten (von - bis) | 6242-6269 |
| Seitenumfang | 28 |
| Fachzeitschrift | Angewandte Chemie - International Edition |
| Jahrgang | 60 |
| Ausgabenummer | 12 |
| Frühes Online-Datum | 16 Jan. 2020 |
| Publikationsstatus | Veröffentlicht - 8 März 2021 |
Abstract
The evolution of coenzymes, or their impact on the origin of life, is fundamental for understanding our own existence. Having established reasonable hypotheses about the emergence of prebiotic chemical building blocks, which were probably created under palaeogeochemical conditions, and surmising that these smaller compounds must have become integrated to afford complex macromolecules such as RNA, the question of coenzyme origin and its relation to the evolution of functional biochemistry should gain new impetus. Many coenzymes have a simple chemical structure and are often nucleotide-derived, which suggests that they may have coexisted with the emergence of RNA and may have played a pivotal role in early metabolism. Based on current theories of prebiotic evolution, which attempt to explain the emergence of privileged organic building blocks, this Review discusses plausible hypotheses on the prebiotic formation of key elements within selected extant coenzymes. In combination with prebiotic RNA, coenzymes may have dramatically broadened early protometabolic networks and the catalytic scope of RNA during the evolution of life.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Allgemeine Chemie
- Chemische Verfahrenstechnik (insg.)
- Katalyse
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in: Angewandte Chemie - International Edition, Jahrgang 60, Nr. 12, 08.03.2021, S. 6242-6269.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Coenzymes and their role in the evolution of Life
AU - Kirschning, Andreas
N1 - Funding Information: I thank Dr. Matthew D. Norris for helpful discussions. Open access funding enabled and organized by Projekt DEAL.
PY - 2021/3/8
Y1 - 2021/3/8
N2 - The evolution of coenzymes, or their impact on the origin of life, is fundamental for understanding our own existence. Having established reasonable hypotheses about the emergence of prebiotic chemical building blocks, which were probably created under palaeogeochemical conditions, and surmising that these smaller compounds must have become integrated to afford complex macromolecules such as RNA, the question of coenzyme origin and its relation to the evolution of functional biochemistry should gain new impetus. Many coenzymes have a simple chemical structure and are often nucleotide-derived, which suggests that they may have coexisted with the emergence of RNA and may have played a pivotal role in early metabolism. Based on current theories of prebiotic evolution, which attempt to explain the emergence of privileged organic building blocks, this Review discusses plausible hypotheses on the prebiotic formation of key elements within selected extant coenzymes. In combination with prebiotic RNA, coenzymes may have dramatically broadened early protometabolic networks and the catalytic scope of RNA during the evolution of life.
AB - The evolution of coenzymes, or their impact on the origin of life, is fundamental for understanding our own existence. Having established reasonable hypotheses about the emergence of prebiotic chemical building blocks, which were probably created under palaeogeochemical conditions, and surmising that these smaller compounds must have become integrated to afford complex macromolecules such as RNA, the question of coenzyme origin and its relation to the evolution of functional biochemistry should gain new impetus. Many coenzymes have a simple chemical structure and are often nucleotide-derived, which suggests that they may have coexisted with the emergence of RNA and may have played a pivotal role in early metabolism. Based on current theories of prebiotic evolution, which attempt to explain the emergence of privileged organic building blocks, this Review discusses plausible hypotheses on the prebiotic formation of key elements within selected extant coenzymes. In combination with prebiotic RNA, coenzymes may have dramatically broadened early protometabolic networks and the catalytic scope of RNA during the evolution of life.
KW - coenzymes
KW - origin of life
KW - prebiotic chemistry
KW - protometabolism
KW - RNA world theory
UR - http://www.scopus.com/inward/record.url?scp=85091618609&partnerID=8YFLogxK
U2 - 10.1002/anie.201914786
DO - 10.1002/anie.201914786
M3 - Article
C2 - 31945250
VL - 60
SP - 6242
EP - 6269
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 0044-8249
IS - 12
ER -