Coenzymes and their role in the evolution of Life

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Titel in ÜbersetzungCoenzyme und ihre Rolle in der Evolution des Lebens
OriginalspracheEnglisch
Seiten (von - bis)6242-6269
Seitenumfang28
FachzeitschriftAngewandte Chemie - International Edition
Jahrgang60
Ausgabenummer12
Frühes Online-Datum16 Jan. 2020
PublikationsstatusVeröffentlicht - 8 März 2021

Abstract

The evolution of coenzymes, or their impact on the origin of life, is fundamental for understanding our own existence. Having established reasonable hypotheses about the emergence of prebiotic chemical building blocks, which were probably created under palaeogeochemical conditions, and surmising that these smaller compounds must have become integrated to afford complex macromolecules such as RNA, the question of coenzyme origin and its relation to the evolution of functional biochemistry should gain new impetus. Many coenzymes have a simple chemical structure and are often nucleotide-derived, which suggests that they may have coexisted with the emergence of RNA and may have played a pivotal role in early metabolism. Based on current theories of prebiotic evolution, which attempt to explain the emergence of privileged organic building blocks, this Review discusses plausible hypotheses on the prebiotic formation of key elements within selected extant coenzymes. In combination with prebiotic RNA, coenzymes may have dramatically broadened early protometabolic networks and the catalytic scope of RNA during the evolution of life.

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Coenzymes and their role in the evolution of Life. / Kirschning, Andreas.
in: Angewandte Chemie - International Edition, Jahrgang 60, Nr. 12, 08.03.2021, S. 6242-6269.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Kirschning A. Coenzymes and their role in the evolution of Life. Angewandte Chemie - International Edition. 2021 Mär 8;60(12):6242-6269. Epub 2020 Jan 16. doi: 10.1002/anie.201914786
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