Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 3593-3599 |
| Seitenumfang | 7 |
| Fachzeitschrift | Analytical chemistry |
| Jahrgang | 96 |
| Ausgabenummer | 8 |
| Frühes Online-Datum | 12 Feb. 2024 |
| Publikationsstatus | Veröffentlicht - 27 Feb. 2024 |
Abstract
Coated blade spray (CBS) is a microextraction technology with blades that serve as both the extraction device and the electrospray ionization (ESI) emitter. CBS is designed for easy and rapid extraction of analytes in complex matrices as well as ESI directly from the blade. The technology selectively enriches the components of interest on a coated metal blade. The coating consists of a selective polymer. So far, CBS has only been coupled with mass spectrometry but never with ion mobility spectrometry (IMS), where ions are separated and detected based on their ion mobility in a drift gas under the influence of an electric field, while instrumentation is compact and easy to operate so that the advantages of CBS can be particularly well exploited. Therefore, this work focuses on coupling CBS with our previously described ESI-IMS. The ion mobility spectrometer has a drift length of only 75 mm and provides a high resolving power of RP = 100. In this work, preliminary measurements of CBS-IMS are presented. In particular, the detection of benzodiazepines and ketamine in drinks and the pesticide isoproturon in water samples is shown to demonstrate the feasibility of CBS-IMS.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Analytische Chemie
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in: Analytical chemistry, Jahrgang 96, Nr. 8, 27.02.2024, S. 3593-3599.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Coated Blade Spray Ion Mobility Spectrometry
AU - Thoben, Christian
AU - Stadtler, Jannie J.
AU - Simon, Paul R.
AU - Raddatz, Christian Robert
AU - Sehlmeyer, Merle
AU - Zimmermann, Stefan
N1 - Funding Information: The authors thank the Restek Corporation for supplying the coated blades and PAS Technology Deutschland GmbH for providing the coated blade spray autosampler.
PY - 2024/2/27
Y1 - 2024/2/27
N2 - Coated blade spray (CBS) is a microextraction technology with blades that serve as both the extraction device and the electrospray ionization (ESI) emitter. CBS is designed for easy and rapid extraction of analytes in complex matrices as well as ESI directly from the blade. The technology selectively enriches the components of interest on a coated metal blade. The coating consists of a selective polymer. So far, CBS has only been coupled with mass spectrometry but never with ion mobility spectrometry (IMS), where ions are separated and detected based on their ion mobility in a drift gas under the influence of an electric field, while instrumentation is compact and easy to operate so that the advantages of CBS can be particularly well exploited. Therefore, this work focuses on coupling CBS with our previously described ESI-IMS. The ion mobility spectrometer has a drift length of only 75 mm and provides a high resolving power of RP = 100. In this work, preliminary measurements of CBS-IMS are presented. In particular, the detection of benzodiazepines and ketamine in drinks and the pesticide isoproturon in water samples is shown to demonstrate the feasibility of CBS-IMS.
AB - Coated blade spray (CBS) is a microextraction technology with blades that serve as both the extraction device and the electrospray ionization (ESI) emitter. CBS is designed for easy and rapid extraction of analytes in complex matrices as well as ESI directly from the blade. The technology selectively enriches the components of interest on a coated metal blade. The coating consists of a selective polymer. So far, CBS has only been coupled with mass spectrometry but never with ion mobility spectrometry (IMS), where ions are separated and detected based on their ion mobility in a drift gas under the influence of an electric field, while instrumentation is compact and easy to operate so that the advantages of CBS can be particularly well exploited. Therefore, this work focuses on coupling CBS with our previously described ESI-IMS. The ion mobility spectrometer has a drift length of only 75 mm and provides a high resolving power of RP = 100. In this work, preliminary measurements of CBS-IMS are presented. In particular, the detection of benzodiazepines and ketamine in drinks and the pesticide isoproturon in water samples is shown to demonstrate the feasibility of CBS-IMS.
UR - http://www.scopus.com/inward/record.url?scp=85185593924&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.3c05586
DO - 10.1021/acs.analchem.3c05586
M3 - Article
AN - SCOPUS:85185593924
VL - 96
SP - 3593
EP - 3599
JO - Analytical chemistry
JF - Analytical chemistry
SN - 0003-2700
IS - 8
ER -