Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 177-180 |
| Seitenumfang | 4 |
| Fachzeitschrift | ACS Macro Letters |
| Jahrgang | 2 |
| Ausgabenummer | 3 |
| Publikationsstatus | Veröffentlicht - 19 März 2013 |
Abstract
Click chemistry is considered to be a good pathway to conjugate chitosan with functional molecules due to the ease of the reaction at room temperature. However, as chitosan forms a complex with metal ions, there is a problem with the existence of metal ions in the derivative. The present work demonstrates that chitosan-oxanorbornadiene can provide metal-free Click by showing the optimal condition to introduce oxanorbornadiene, with 80% substitution, and clarifies model reactions of chitosan with azido-modified substrates for the ligation of bioactive molecules.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Organische Chemie
- Werkstoffwissenschaften (insg.)
- Polymere und Kunststoffe
- Chemie (insg.)
- Anorganische Chemie
- Werkstoffwissenschaften (insg.)
- Werkstoffchemie
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in: ACS Macro Letters, Jahrgang 2, Nr. 3, 19.03.2013, S. 177-180.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Chitosan-oxanorbornadiene
T2 - A convenient chitosan derivative for click chemistry without metal catalyst problem
AU - Jirawutthiwongchai, Jatesuda
AU - Krause, Andreas
AU - Draeger, Gerald
AU - Chirachanchai, Suwabun
N1 - Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2013/3/19
Y1 - 2013/3/19
N2 - Click chemistry is considered to be a good pathway to conjugate chitosan with functional molecules due to the ease of the reaction at room temperature. However, as chitosan forms a complex with metal ions, there is a problem with the existence of metal ions in the derivative. The present work demonstrates that chitosan-oxanorbornadiene can provide metal-free Click by showing the optimal condition to introduce oxanorbornadiene, with 80% substitution, and clarifies model reactions of chitosan with azido-modified substrates for the ligation of bioactive molecules.
AB - Click chemistry is considered to be a good pathway to conjugate chitosan with functional molecules due to the ease of the reaction at room temperature. However, as chitosan forms a complex with metal ions, there is a problem with the existence of metal ions in the derivative. The present work demonstrates that chitosan-oxanorbornadiene can provide metal-free Click by showing the optimal condition to introduce oxanorbornadiene, with 80% substitution, and clarifies model reactions of chitosan with azido-modified substrates for the ligation of bioactive molecules.
UR - http://www.scopus.com/inward/record.url?scp=84875345558&partnerID=8YFLogxK
U2 - 10.1021/mz400006j
DO - 10.1021/mz400006j
M3 - Article
AN - SCOPUS:84875345558
VL - 2
SP - 177
EP - 180
JO - ACS Macro Letters
JF - ACS Macro Letters
SN - 2161-1653
IS - 3
ER -