Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1489-1492 |
| Seitenumfang | 4 |
| Fachzeitschrift | Organic Letters |
| Jahrgang | 9 |
| Ausgabenummer | 8 |
| Publikationsstatus | Veröffentlicht - 23 März 2007 |
Abstract
Equation Presented The enantioselective total synthesis of proansamitocin, a key biosynthetic intermediate of the highly potent antitumor agent ansamitocin P-3, is described which bears a diene-ene RCM as the key macrocyclization step. Feeding of proansamitocin to an AHBA block mutant Actinosynnema pretiosum (HGF073) yielded ansamitocin P-3 as well as dechloroansamitocin P-3, the latter also being formed upon fermentation in the presence of 3-amino-5-methoxybenzoic acid.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Chemie (insg.)
- Physikalische und Theoretische Chemie
- Chemie (insg.)
- Organische Chemie
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in: Organic Letters, Jahrgang 9, Nr. 8, 23.03.2007, S. 1489-1492.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Chemoenzymatic approaches toward dechloroansamitocin P-3
AU - Meyer, Axel
AU - Brünjes, Marco
AU - Taft, Florian
AU - Frenzel, Thomas
AU - Sasse, Florenz
AU - Kirschning, Andreas
PY - 2007/3/23
Y1 - 2007/3/23
N2 - Equation Presented The enantioselective total synthesis of proansamitocin, a key biosynthetic intermediate of the highly potent antitumor agent ansamitocin P-3, is described which bears a diene-ene RCM as the key macrocyclization step. Feeding of proansamitocin to an AHBA block mutant Actinosynnema pretiosum (HGF073) yielded ansamitocin P-3 as well as dechloroansamitocin P-3, the latter also being formed upon fermentation in the presence of 3-amino-5-methoxybenzoic acid.
AB - Equation Presented The enantioselective total synthesis of proansamitocin, a key biosynthetic intermediate of the highly potent antitumor agent ansamitocin P-3, is described which bears a diene-ene RCM as the key macrocyclization step. Feeding of proansamitocin to an AHBA block mutant Actinosynnema pretiosum (HGF073) yielded ansamitocin P-3 as well as dechloroansamitocin P-3, the latter also being formed upon fermentation in the presence of 3-amino-5-methoxybenzoic acid.
UR - http://www.scopus.com/inward/record.url?scp=34247513512&partnerID=8YFLogxK
U2 - 10.1021/ol0702270
DO - 10.1021/ol0702270
M3 - Article
C2 - 17378571
AN - SCOPUS:34247513512
VL - 9
SP - 1489
EP - 1492
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 8
ER -