TY - JOUR

T1 - Chemical Functionalization of Polysaccharides

T2 - Towards Biocompatible Hydrogels for Biomedical Applications

AU - Kirschning, Andreas

AU - Dibbert, Nick

AU - Dräger, Gerald

N1 - Funding information: We are indebted to the Deutsche Forschungsgemeinschaft (DFG) for research on biocompatible polysaccharide-based hydrogels as part of the Cluster of Excellence REBIRTH; “From Regenerative Biology to Reconstructive Therapy” EXC 62). Additionally, this work has been carried out as an integral part of the BIOFABRICATION FOR NIFE Initiative, which is financially supported by the ministry of Lower Saxony and the Volkswagen Stiftung (NIFE is the Lower Saxony Center for Biomedical Engineering, Implant Research and Development, a joint translational research center of the Hannover Medical School, the Leibniz Universität Hannover, the University of Veterinary Medicine Hannover and the Laser Center Hannover. We thank Dr. M. D. Norris for helpful discussions.

PY - 2017/8/13

Y1 - 2017/8/13

N2 - Hydrogels have emerged as a highly interdisciplinary topic as they play a significant role for a vast number of applications. They have been studied extensively as materials for contact lenses, wound dressing and as filler material in soft-tissue augmentation, in which classical polymer backbones such as hydroxyethylmethacrylate (HEMA) are typically employed. More recently, polysaccharides have received attention, particularly in the fields of regenerative medicine and tissue engineering, as ideal candidate materials for artificial extracellular matrices (ECM). The polysaccharides of choice are dextran, alginate, chitosan, hyaluronic acid and pullulan and in order to obtain suitable hydrogels from these polysaccharides, controlled chemical functionalization is of critical importance. This short review summarizes recent developments in the chemical derivatization of polysaccharides to pave the way for crosslinking and to decorate individual polysaccharide chains with bioactive ligands. The report covers convergent and divergent protocols for crosslinking, as well strategies for bisfunctionalization of polysaccharides. Additionally, information on biological properties and biomedical applications are covered.

AB - Hydrogels have emerged as a highly interdisciplinary topic as they play a significant role for a vast number of applications. They have been studied extensively as materials for contact lenses, wound dressing and as filler material in soft-tissue augmentation, in which classical polymer backbones such as hydroxyethylmethacrylate (HEMA) are typically employed. More recently, polysaccharides have received attention, particularly in the fields of regenerative medicine and tissue engineering, as ideal candidate materials for artificial extracellular matrices (ECM). The polysaccharides of choice are dextran, alginate, chitosan, hyaluronic acid and pullulan and in order to obtain suitable hydrogels from these polysaccharides, controlled chemical functionalization is of critical importance. This short review summarizes recent developments in the chemical derivatization of polysaccharides to pave the way for crosslinking and to decorate individual polysaccharide chains with bioactive ligands. The report covers convergent and divergent protocols for crosslinking, as well strategies for bisfunctionalization of polysaccharides. Additionally, information on biological properties and biomedical applications are covered.

KW - click chemistry

KW - crosslinking

KW - hydrogels

KW - polysaccharides

KW - tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85032952387&partnerID=8YFLogxK

U2 - 10.1002/chem.201701906

DO - 10.1002/chem.201701906

M3 - Article

C2 - 28804933

AN - SCOPUS:85032952387

VL - 24

SP - 1231

EP - 1240

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 6

ER -